ENSG00000103194


Homo sapiens

Features
Gene ID: ENSG00000103194
  
Biological name :USP10
  
Synonyms : Q14694 / ubiquitin specific peptidase 10 / USP10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q24.1
Gene start: 84699978
Gene end: 84779922
  
Corresponding Affymetrix probe sets: 209136_s_at (Human Genome U133 Plus 2.0 Array)   209137_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462762
Ensembl peptide - ENSP00000457411
Ensembl peptide - ENSP00000458089
Ensembl peptide - ENSP00000219473
Ensembl peptide - ENSP00000445589
Ensembl peptide - ENSP00000454751
Ensembl peptide - ENSP00000454902
Ensembl peptide - ENSP00000454943
Ensembl peptide - ENSP00000454987
Ensembl peptide - ENSP00000455712
Ensembl peptide - ENSP00000455865
NCBI entrez gene - 9100     See in Manteia.
OMIM - 609818
RefSeq - XM_017023869
RefSeq - NM_001272075
RefSeq - NM_005153
RefSeq - XM_006721332
RefSeq - XM_011523440
RefSeq - XM_011523441
RefSeq - XM_011523443
RefSeq - XM_017023863
RefSeq - XM_017023864
RefSeq - XM_017023865
RefSeq - XM_017023866
RefSeq - XM_017023867
RefSeq - XM_017023868
RefSeq Peptide - NP_005144
RefSeq Peptide - NP_001259004
swissprot - H3BNS8
swissprot - H3BQC6
swissprot - H3BQP1
swissprot - H3BVF1
swissprot - J3KT19
swissprot - Q68D90
swissprot - H3BNA1
swissprot - H3BNL0
swissprot - Q14694
swissprot - H3BNP1
Ensembl - ENSG00000103194
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp10ENSDARG00000103422Danio rerio
 USP10ENSGALG00000005674Gallus gallus
 Usp10ENSMUSG00000031826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR009818  Ataxin-2, C-terminal
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0010506 regulation of autophagy IDA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0071347 cellular response to interleukin-1 IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0044325 ion channel binding IDA


Pathways (from Reactome)
Pathway description
Termination of translesion DNA synthesis
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000001626 CFTR / P13569 / cystic fibrosis transmembrane conductance regulator  / complex
 ENSG00000058056 USP13 / Q92995 / ubiquitin specific peptidase 13  / complex
 ENSG00000112335 SNX3 / O60493 / sorting nexin 3  / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex






 

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