Manteia

ENSMUSG00000031826

Mus musculus

Features

Gene ID:	ENSMUSG00000031826

Biological name :	Usp10

Synonyms :	P52479 / ubiquitin specific peptidase 10 / Usp10

Possible biological names infered from orthology :	Q14694

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	E1
Gene start:	119910360
Gene end:	119957560

Corresponding Affymetrix probe sets:	10575961 (MoGene1.0st) 1448230_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000104610 Ensembl peptide - ENSMUSP00000104616 Ensembl peptide - ENSMUSP00000123590 Ensembl peptide - ENSMUSP00000134182 NCBI entrez gene - 22224 See in Manteia. MGI - MGI:894652 RefSeq - XM_006530845 RefSeq - XM_006530846 RefSeq - NM_001310630 RefSeq - NM_009462 RefSeq Peptide - NP_001297559 RefSeq Peptide - NP_033488 swissprot - P52479 swissprot - G3X9U6 swissprot - G3UYQ8 Ensembl - ENSMUSG00000031826

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
usp10	ENSDARG00000103422	Danio rerio
USP10	ENSGALG00000005674	Gallus gallus
USP10	ENSG00000103194	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR009818	Ataxin-2, C-terminal
IPR018200	Ubiquitin specific protease, conserved site
IPR028889	Ubiquitin specific protease domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0006914	autophagy	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	ISO
biological_process	GO:0010506	regulation of autophagy	IBA
biological_process	GO:0016579	protein deubiquitination	IEA
biological_process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	IBA
biological_process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISS
biological_process	GO:0071347	cellular response to interleukin-1	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005769	early endosome	IBA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0032991	protein-containing complex	ISS
molecular_function	GO:0002039	p53 binding	ISS
molecular_function	GO:0004197	cysteine-type endopeptidase activity	ISS
molecular_function	GO:0004843	thiol-dependent ubiquitin-specific protease activity	ISS
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008234	cysteine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA
molecular_function	GO:0044325	ion channel binding	ISO

Pathways (from Reactome)

Pathway description

Termination of translesion DNA synthesis

Ub-specific processing proteases

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan,Tg(T-cre)1Lwd/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0003674	oxidative stress	"condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan,Tg(T-cre)1Lwd/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan,Tg(T-cre)1Lwd/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000059552	Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*	/ complex
ENSMUSG00000019804	Snx3 / sorting nexin 3 / O60493*	/ complex
ENSMUSG00000041301	Cftr / P26361 / Cystic fibrosis transmembrane conductance regulator / P13569*	/ complex
ENSMUSG00000056900	Usp13 / Q5BKP2 / ubiquitin specific peptidase 13 (isopeptidase T-3) / Q92995* / ubiquitin specific peptidase 13*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr