ENSG00000112335


Homo sapiens

Features
Gene ID: ENSG00000112335
  
Biological name :SNX3
  
Synonyms : O60493 / SNX3 / sorting nexin 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q21
Gene start: 108211222
Gene end: 108261260
  
Corresponding Affymetrix probe sets: 200067_x_at (Human Genome U133 Plus 2.0 Array)   208781_x_at (Human Genome U133 Plus 2.0 Array)   210648_x_at (Human Genome U133 Plus 2.0 Array)   213545_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000230085
Ensembl peptide - ENSP00000296991
Ensembl peptide - ENSP00000357975
Ensembl peptide - ENSP00000401779
NCBI entrez gene - 8724     See in Manteia.
OMIM - 605930
RefSeq - NM_001300929
RefSeq - NM_001300928
RefSeq - NM_003795
RefSeq - NM_152827
RefSeq Peptide - NP_001287857
RefSeq Peptide - NP_001287858
RefSeq Peptide - NP_003786
RefSeq Peptide - NP_690040
swissprot - O60493
Ensembl - ENSG00000112335
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snx3ENSDARG00000008678Danio rerio
 SNX3ENSGALG00000015304Gallus gallus
 Snx3ENSMUSG00000019804Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SNX12 / Q9UMY4 / sorting nexin 12ENSG0000014716478
SNX11 / Q9Y5W9 / sorting nexin 11ENSG0000000291927
SNX10 / Q9Y5X0 / sorting nexin 10ENSG0000008630025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001683  Phox homologous domain
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0010324 membrane invagination IDA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0022615 protein to membrane docking IDA
 biological_processGO:0030111 regulation of Wnt signaling pathway IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0046597 negative regulation of viral entry into host cell IDA
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:0051224 negative regulation of protein transport IDA
 biological_processGO:0070676 intralumenal vesicle formation IMP
 biological_processGO:2000642 negative regulation of early endosome to late endosome transport IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0019898 extrinsic component of membrane IBA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030904 retromer complex IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IDA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0010314 phosphatidylinositol-5-phosphate binding ISS
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding ISS
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding ISS


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103194 USP10 / Q14694 / ubiquitin specific peptidase 10  / complex
 ENSG00000122958 O75436 / VPS26A / VPS26, retromer complex component A  / complex / reaction
 ENSG00000116729 WLS / Q5T9L3 / wntless Wnt ligand secretion mediator  / reaction / complex
 ENSG00000069329 VPS35 / Q96QK1 / VPS35, retromer complex component  / complex / reaction
 ENSG00000111237 VPS29 / Q9UBQ0 / VPS29, retromer complex component  / complex / reaction






 

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