ENSG00000069329


Homo sapiens

Features
Gene ID: ENSG00000069329
  
Biological name :VPS35
  
Synonyms : Q96QK1 / VPS35 / VPS35, retromer complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q11.2
Gene start: 46656132
Gene end: 46689518
  
Corresponding Affymetrix probe sets: 217727_x_at (Human Genome U133 Plus 2.0 Array)   222387_s_at (Human Genome U133 Plus 2.0 Array)   222388_s_at (Human Genome U133 Plus 2.0 Array)   233864_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299138
Ensembl peptide - ENSP00000461423
Ensembl peptide - ENSP00000461469
Ensembl peptide - ENSP00000491212
Ensembl peptide - ENSP00000456274
NCBI entrez gene - 55737     See in Manteia.
OMIM - 601501
RefSeq - XM_011523227
RefSeq - NM_018206
RefSeq - XM_005256045
RefSeq Peptide - NP_060676
swissprot - I3L4S0
swissprot - A0A1W2PP10
swissprot - Q96QK1
swissprot - H3BRJ7
swissprot - I3L4P4
Ensembl - ENSG00000069329
  
Related genetic diseases (OMIM): 614203 - {Parkinson disease 17}, 614203
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps35ENSDARG00000008224Danio rerio
 VPS35ENSGALG00000004375Gallus gallus
 Vps35ENSMUSG00000031696Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005378  Vacuolar protein sorting-associated protein 35
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010821 regulation of mitochondrion organization IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway NAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032268 regulation of cellular protein metabolic process IGI
 biological_processGO:0032463 negative regulation of protein homooligomerization IEA
 biological_processGO:0033365 protein localization to organelle IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi NAS
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IMP
 biological_processGO:0045056 transcytosis IDA
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0050882 voluntary musculoskeletal movement IEA
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway IDA
 biological_processGO:0060548 negative regulation of cell death IGI
 biological_processGO:0061357 positive regulation of Wnt protein secretion IEA
 biological_processGO:0090141 positive regulation of mitochondrial fission IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090326 positive regulation of locomotion involved in locomotory behavior IEA
 biological_processGO:0099074 mitochondrion to lysosome transport IMP
 biological_processGO:0099639 neurotransmitter receptor transport, endosome to plasma membrane IDA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902823 negative regulation of late endosome to lysosome transport IMP
 biological_processGO:1902950 regulation of dendritic spine maintenance IMP
 biological_processGO:1903181 positive regulation of dopamine biosynthetic process IEA
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IGI
 biological_processGO:1903828 negative regulation of cellular protein localization IEA
 biological_processGO:1905166 negative regulation of lysosomal protein catabolic process IEA
 biological_processGO:1905606 regulation of presynapse assembly ISS
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IMP
 biological_processGO:2000331 regulation of terminal button organization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030904 retromer complex IEA
 cellular_componentGO:0030906 retromer, cargo-selective complex NAS
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097422 tubular endosome IDA
 cellular_componentGO:0099073 mitochondrion-derived vesicle IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IBA
 molecular_functionGO:0031748 D1 dopamine receptor binding IPI


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122958 O75436 / VPS26A / VPS26, retromer complex component A  / complex
 ENSG00000112335 SNX3 / O60493 / sorting nexin 3  / complex / reaction
 ENSG00000116729 WLS / Q5T9L3 / wntless Wnt ligand secretion mediator  / reaction / complex
 ENSG00000111237 VPS29 / Q9UBQ0 / VPS29, retromer complex component  / complex






 

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