ENSMUSG00000031696


Mus musculus

Features
Gene ID: ENSMUSG00000031696
  
Biological name :Vps35
  
Synonyms : Q9EQH3 / Vps35 / VPS35 retromer complex component
  
Possible biological names infered from orthology : Q96QK1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C3
Gene start: 85260392
Gene end: 85299802
  
Corresponding Affymetrix probe sets: 10580331 (MoGene1.0st)   1415783_at (Mouse Genome 430 2.0 Array)   1415784_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034131
NCBI entrez gene - 65114     See in Manteia.
MGI - MGI:1890467
RefSeq - NM_022997
RefSeq Peptide - NP_075373
swissprot - Q3TRJ1
swissprot - Q9EQH3
Ensembl - ENSMUSG00000031696
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps35ENSDARG00000008224Danio rerio
 VPS35ENSGALG00000004375Gallus gallus
 VPS35ENSG00000069329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005378  Vacuolar protein sorting-associated protein 35
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006624 vacuolar protein processing ISA
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010821 regulation of mitochondrion organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0032268 regulation of cellular protein metabolic process IEA
 biological_processGO:0032463 negative regulation of protein homooligomerization IMP
 biological_processGO:0033365 protein localization to organelle IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi IC
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IEA
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050882 voluntary musculoskeletal movement IMP
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061357 positive regulation of Wnt protein secretion IMP
 biological_processGO:0090141 positive regulation of mitochondrial fission IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0090326 positive regulation of locomotion involved in locomotory behavior IMP
 biological_processGO:0099074 mitochondrion to lysosome transport ISO
 biological_processGO:0099639 neurotransmitter receptor transport, endosome to plasma membrane IMP
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902823 negative regulation of late endosome to lysosome transport ISO
 biological_processGO:1902950 regulation of dendritic spine maintenance ISO
 biological_processGO:1903181 positive regulation of dopamine biosynthetic process IMP
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IEA
 biological_processGO:1903828 negative regulation of cellular protein localization IMP
 biological_processGO:1905166 negative regulation of lysosomal protein catabolic process IMP
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IEA
 biological_processGO:2000331 regulation of terminal button organization ISO
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005770 late endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISA
 cellular_componentGO:0030904 retromer complex IEA
 cellular_componentGO:0030906 retromer, cargo-selective complex ISO
 cellular_componentGO:0043005 neuron projection IMP
 cellular_componentGO:0043025 neuronal cell body IMP
 cellular_componentGO:0048471 perinuclear region of cytoplasm IMP
 cellular_componentGO:0097422 tubular endosome IEA
 cellular_componentGO:0099073 mitochondrion-derived vesicle ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IBA
 molecular_functionGO:0031748 D1 dopamine receptor binding IPI


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Usp7tm2Wgu/Usp7tm2Wgu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019804 Snx3 / sorting nexin 3 / O60493*  / reaction / complex
 ENSMUSG00000028173 Wls / Q6DID7 / wntless WNT ligand secretion mediator / Q5T9L3*  / complex / reaction
 ENSMUSG00000020078 P40336 / Vps26a / VPS26 retromer complex component A / O75436*  / complex
 ENSMUSG00000029462 Vps29 / Q9QZ88 / VPS29 retromer complex component / Q9UBQ0*  / complex






 

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