ENSMUSG00000020078


Mus musculus

Features
Gene ID: ENSMUSG00000020078
  
Biological name :Vps26a
  
Synonyms : P40336 / Vps26a / VPS26 retromer complex component A
  
Possible biological names infered from orthology : O75436
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 62455235
Gene end: 62486805
  
Corresponding Affymetrix probe sets: 10369604 (MoGene1.0st)   1420495_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151774
Ensembl peptide - ENSMUSP00000151888
Ensembl peptide - ENSMUSP00000090130
Ensembl peptide - ENSMUSP00000101087
NCBI entrez gene - 30930     See in Manteia.
MGI - MGI:1353654
RefSeq - NM_133672
RefSeq - XM_006513734
RefSeq - NM_001113355
RefSeq Peptide - NP_001106826
RefSeq Peptide - NP_598433
swissprot - A0A1W2P7R7
swissprot - P40336
swissprot - A0A1W2P7Z9
Ensembl - ENSMUSG00000020078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6TNP8ENSDARG00000056549Danio rerio
 VPS26AENSGALG00000004174Gallus gallus
 O75436ENSG00000122958Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C0E2 / Vps26b / VPS26 retromer complex component B / Q4G0F5*ENSMUSG0000003198862


Protein motifs (from Interpro)
Interpro ID Name
 IPR028934  Vacuolar protein sorting protein 26 related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISO
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030904 retromer complex TAS
 cellular_componentGO:0030906 retromer, cargo-selective complex ISO
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0097422 tubular endosome ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IBA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Snx1tm1Mag/Snx1tm1Mag,Snx2tm1Mag/Snx2+,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028173 Wls / Q6DID7 / wntless WNT ligand secretion mediator / Q5T9L3*  / complex / reaction
 ENSMUSG00000029462 Vps29 / Q9QZ88 / VPS29 retromer complex component / Q9UBQ0*  / complex
 ENSMUSG00000019804 Snx3 / sorting nexin 3 / O60493*  / complex / reaction
 ENSMUSG00000031696 Vps35 / Q9EQH3 / VPS35 retromer complex component / Q96QK1*  / complex






 

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