ENSG00000116729


Homo sapiens

Features
Gene ID: ENSG00000116729
  
Biological name :WLS
  
Synonyms : Q5T9L3 / WLS / wntless Wnt ligand secretion mediator
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p31.3
Gene start: 68098473
Gene end: 68233120
  
Corresponding Affymetrix probe sets: 221958_s_at (Human Genome U133 Plus 2.0 Array)   228949_at (Human Genome U133 Plus 2.0 Array)   228950_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360015
Ensembl peptide - ENSP00000431552
Ensembl peptide - ENSP00000436196
Ensembl peptide - ENSP00000433867
Ensembl peptide - ENSP00000433690
Ensembl peptide - ENSP00000433188
Ensembl peptide - ENSP00000433111
Ensembl peptide - ENSP00000262348
Ensembl peptide - ENSP00000346829
Ensembl peptide - ENSP00000360010
Ensembl peptide - ENSP00000360012
NCBI entrez gene - 79971     See in Manteia.
OMIM - 611514
RefSeq - XM_017002390
RefSeq - NM_001002292
RefSeq - NM_001193334
RefSeq - NM_024911
RefSeq - XM_011542191
RefSeq - XM_011542192
RefSeq Peptide - NP_079187
RefSeq Peptide - NP_001002292
RefSeq Peptide - NP_001180263
swissprot - E9PQK1
swissprot - E9PM62
swissprot - E9PM23
swissprot - E9PKJ0
swissprot - E9PJW4
swissprot - H0YDL2
swissprot - H0YCG9
swissprot - Q5T9L3
swissprot - Q7Z430
Ensembl - ENSG00000116729
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wlsENSDARG00000009534Danio rerio
 WLSENSGALG00000011238Gallus gallus
 WlsENSMUSG00000028173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009551  Protein wntless


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0006886 intracellular protein transport IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009948 anterior/posterior axis specification ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0031017 exocrine pancreas development IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0061355 Wnt protein secretion IMP
 biological_processGO:0061357 positive regulation of Wnt protein secretion ISS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome TAS
 molecular_functionGO:0004871 obsolete signal transducer activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0031852 mu-type opioid receptor binding IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122958 O75436 / VPS26A / VPS26, retromer complex component A  / complex / reaction
 ENSG00000112335 SNX3 / O60493 / sorting nexin 3  / reaction / complex
 ENSG00000069329 VPS35 / Q96QK1 / VPS35, retromer complex component  / complex / reaction
 ENSG00000111237 VPS29 / Q9UBQ0 / VPS29, retromer complex component  / reaction / complex






 

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