ENSDARG00000009534


Danio rerio

Features
Gene ID: ENSDARG00000009534
  
Biological name :wls
  
Synonyms : wls / wntless Wnt ligand secretion mediator
  
Possible biological names infered from orthology : Q5T9L3 / Q6DID7
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 10342177
Gene end: 10386738
  
Corresponding Affymetrix probe sets: Dr.26538.1.A1_at (Zebrafish Array)   Dr.3546.1.S1_at (Zebrafish Array)   Dr.3546.1.S1_s_at (Zebrafish Array)   NM_213146_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000016104
NCBI entrez gene - 406420     See in Manteia.
RefSeq - NM_213146
RefSeq Peptide - NP_998311
swissprot - F2Z4U3
ZFIN ID - ZDB-GENE-040426-2161
Ensembl - ENSDARG00000009534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WLSENSGALG00000011238Gallus gallus
 WLSENSG00000116729Homo sapiens
 WlsENSMUSG00000028173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009551  Protein wntless


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021986 habenula development IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060872 semicircular canal development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain disorganized , abnormal
brain malformed , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure absent , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary poorly differentiated , abnormal
midbrain hindbrain boundary aplastic , abnormal
midbrain hindbrain boundary absent , abnormal
midbrain hindbrain boundary decreased amount , abnormal
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 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle decreased amount , abnormal
Show

 ZFA:0000101 diencephalon diencephalon absent , abnormal
diencephalon decreased distribution , abnormal
diencephalon dorsal region decreased amount , abnormal
diencephalon dorsal region absent , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000191 dentary dentary absent , abnormal
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 ZFA:0000197 dorsal habenular nucleus dorsal habenular nucleus decreased distribution , abnormal
dorsal habenular nucleus decreased amount , abnormal
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 ZFA:0000213 habenula habenula decreased distribution , abnormal
habenula decreased amount , abnormal
Show

 ZFA:0000217 inner ear inner ear malformed , abnormal
Show

 ZFA:0000270 maxilla maxilla absent , abnormal
Show

 ZFA:0000302 ventral habenular nucleus ventral habenular nucleus absent , abnormal
Show

 ZFA:0000422 retroarticular retroarticular malformed , abnormal
retroarticular shortened , abnormal
retroarticular absent , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal morphology , abnormal
Show

 ZFA:0000476 branchiostegal ray branchiostegal ray absent , abnormal
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 ZFA:0000509 epithalamus epithalamus decreased distribution , abnormal
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 ZFA:0000621 quadrate quadrate absent , abnormal
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 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region curved lateral , abnormal
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 ZFA:0001128 pharyngeal pouch 1 pharyngeal pouch 1 decreased object quality , abnormal
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 ZFA:0001130 pharyngeal pouch 2 pharyngeal pouch 2 decreased object quality , abnormal
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 ZFA:0001161 pectoral fin pectoral fin morphology , abnormal
pectoral fin decreased size , abnormal
pectoral fin decreased amount , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage dislocated , abnormal
Meckels cartilage increased amount , abnormal
Meckels cartilage shortened , abnormal
Meckels cartilage cartilage morphogenesis process quality , abnormal
Meckels cartilage chondrocyte morphology , abnormal
Meckels cartilage chondrocyte positional polarity , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased amount , abnormal
mandibular arch skeleton morphology , abnormal
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 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone absent , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch cell proliferation decreased occurrence , abnormal
pharyngeal arch cartilage development decreased process quality , abnormal
pharyngeal arch Wnt protein secretion decreased occurrence , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage dislocated , abnormal
Show

 ZFA:0001511 interhyal cartilage interhyal cartilage chondrocyte decreased amount , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage malformed , abnormal
Show

 ZFA:0001591 endochondral bone endochondral bone absent , abnormal
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 ZFA:0001630 perichondral bone perichondral bone absent , abnormal
Show

 ZFA:0001652 head muscle head muscle decreased length , abnormal
Show

 ZFA:0005484 quadrate-anguloarticular joint quadrate-anguloarticular joint morphology , abnormal
Show

 ZFA:0005509 palate palate decreased length , abnormal
palate increased width , abnormal
palate chondrocyte irregular spatial pattern , abnormal
palate chondrocyte circular , abnormal
palate chondrocyte decreased size , abnormal
palate cell migration process quality , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte microtubule organizing center disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000069521 vps29 / Q7ZV68 / vacuolar protein sorting 29 homolog (S. cerevisiae) / Q9UBQ0* / Q9QZ88* / VPS29, retromer complex component*  / reaction / complex
 ENSDARG00000056549 Q6TNP8 / vps26a / vacuolar protein sorting 26 homolog A (S. pombe) / O75436* / P40336* / VPS26, retromer complex component A*  / reaction / complex
 ENSDARG00000008224 vps35 / vacuolar protein sorting 35 homolog (S. cerevisiae) / Q96QK1* / Q9EQH3* / VPS35, retromer complex component*  / reaction / complex
 ENSDARG00000008678 snx3 / sorting nexin 3 / O60493*  / reaction / complex






 

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