ENSMUSG00000017499


Mus musculus

Features
Gene ID: ENSMUSG00000017499
  
Biological name :Cdc6
  
Synonyms : Cdc6 / Cell division control / O89033
  
Possible biological names infered from orthology : cell division cycle 6 / Q99741
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98907801
Gene end: 98923940
  
Corresponding Affymetrix probe sets: 10381072 (MoGene1.0st)   1417019_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118421
Ensembl peptide - ENSMUSP00000090382
Ensembl peptide - ENSMUSP00000091469
NCBI entrez gene - 23834     See in Manteia.
MGI - MGI:1345150
RefSeq - XM_017314547
RefSeq - NM_001025779
RefSeq - NM_011799
RefSeq - XM_017314546
RefSeq Peptide - NP_001020950
RefSeq Peptide - NP_035929
swissprot - E9PY34
swissprot - O89033
swissprot - A0A0R4J145
Ensembl - ENSMUSG00000017499
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc6ENSDARG00000009942Danio rerio
 CDC6ENSGALG00000036519Gallus gallus
 CDC6ENSG00000094804Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Orc1 / Q9Z1N2 / Origin recognition complex subunit 1 / Q13415*ENSMUSG0000002858723


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR015163  Cdc6, C-terminal
 IPR016314  Cell division protein Cdc6/18
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle ISO
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition ISO
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051984 positive regulation of chromosome segregation ISO
 biological_processGO:1904117 cellular response to vasopressin IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0051233 spindle midzone ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019900 kinase binding ISO


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000006585 Cdt1 / Q8R4E9 / DNA replication factor Cdt1 / Q9H211* / chromatin licensing and DNA replication factor 1*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000026669 Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*  / reaction / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000028212 Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*  / reaction
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / complex / reaction
 ENSMUSG00000029283 Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*  / complex / reaction
 ENSMUSG00000000028 Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*  / reaction / complex
 ENSMUSG00000002297 A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*  / reaction / complex
 ENSMUSG00000002068 Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex






 

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