ENSMUSG00000006585


Mus musculus

Features
Gene ID: ENSMUSG00000006585
  
Biological name :Cdt1
  
Synonyms : Cdt1 / DNA replication factor Cdt1 / Q8R4E9
  
Possible biological names infered from orthology : chromatin licensing and DNA replication factor 1 / Q9H211
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 122568015
Gene end: 122573554
  
Corresponding Affymetrix probe sets: 10576140 (MoGene1.0st)   1424143_a_at (Mouse Genome 430 2.0 Array)   1424144_at (Mouse Genome 430 2.0 Array)   1455791_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006760
NCBI entrez gene - 67177     See in Manteia.
MGI - MGI:1914427
RefSeq - NM_026014
RefSeq Peptide - NP_080290
swissprot - Q8R4E9
Ensembl - ENSMUSG00000006585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdt1ENSDARG00000051854Danio rerio
 CDT1ENSGALG00000013784Gallus gallus
 CDT1ENSG00000167513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014939  CDT1 Geminin-binding domain-like
 IPR032054  DNA replication factor Cdt1, C-terminal
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000076 DNA replication checkpoint IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0030174 regulation of DNA-dependent DNA replication initiation IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0033044 regulation of chromosome organization IEA
 biological_processGO:0033262 regulation of nuclear cell cycle DNA replication IDA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0051276 chromosome organization IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IEA
 biological_processGO:0051383 kinetochore organization IEA
 biological_processGO:0071163 DNA replication preinitiation complex assembly IEA
 biological_processGO:0072708 response to sorbitol IEA
 biological_processGO:1902426 deactivation of mitotic spindle assembly checkpoint IEA
 biological_processGO:1902595 regulation of DNA replication origin binding IEA
 biological_processGO:1905341 negative regulation of protein localization to kinetochore IEA
 biological_processGO:1905342 positive regulation of protein localization to kinetochore IEA
 biological_processGO:2000105 positive regulation of DNA-dependent DNA replication IEA
 biological_processGO:2001178 positive regulation of mediator complex assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: D2.B10-Dmdmdx/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006715 Gmnn / O88513 / geminin / O75496* / geminin, DNA replication inhibitor*  / reaction / complex
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / reaction / complex
 ENSMUSG00000026669 Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction






 

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