ENSMUSG00000006715


Mus musculus

Features
Gene ID: ENSMUSG00000006715
  
Biological name :Gmnn
  
Synonyms : geminin / Gmnn / O88513
  
Possible biological names infered from orthology : geminin, DNA replication inhibitor / O75496
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 24751845
Gene end: 24761923
  
Corresponding Affymetrix probe sets: 10408321 (MoGene1.0st)   1417506_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134986
Ensembl peptide - ENSMUSP00000006898
Ensembl peptide - ENSMUSP00000106011
Ensembl peptide - ENSMUSP00000135006
Ensembl peptide - ENSMUSP00000135823
NCBI entrez gene - 57441     See in Manteia.
MGI - MGI:1927344
RefSeq - XM_006516723
RefSeq - NM_020567
RefSeq Peptide - NP_065592
swissprot - H3BJJ1
swissprot - H3BJH3
swissprot - O88513
swissprot - Q3V295
swissprot - H3BLK4
Ensembl - ENSMUSG00000006715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gmnnENSDARG00000035957Danio rerio
 GMNNENSGALG00000013626Gallus gallus
 GMNNENSG00000112312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcidas / Q3UZ45 / Multicilin / D6RGH6* / multiciliate differentiation and DNA synthesis associated cell cycle protein*ENSMUSG0000007465123


Protein motifs (from Interpro)
Interpro ID Name
 IPR022786  Geminin/Multicilin
 IPR029697  Geminin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0009887 animal organ morphogenesis IDA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0065003 protein-containing complex assembly IDA
 biological_processGO:0071163 DNA replication preinitiation complex assembly IEA
 biological_processGO:2000104 negative regulation of DNA-dependent DNA replication IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042826 histone deacetylase binding ISS
 molecular_functionGO:0070491 repressing transcription factor binding IPI


Pathways (from Reactome)
Pathway description
CDT1 association with the CDC6:ORC:origin complex
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoa2a/Apoa2a
Genetic Background: SAMP3

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Gap43tm1a(EUCOMM)Wtsi/Gap43+
Genetic Background: B6JTyr;B6N-Gap43tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Gap43tm1a(EUCOMM)Wtsi/Gap43+
Genetic Background: B6JTyr;B6N-Gap43tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Gmnntm1Tjm/Gmnn+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoa2a/Apoa2a
Genetic Background: SAMP3

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0011903 decreased hematopoietic stem cell proliferation "reduction in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0012102 absent trophectoderm "absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo s means of nutrition" [MGI:anna]
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Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006585 Cdt1 / Q8R4E9 / DNA replication factor Cdt1 / Q9H211* / chromatin licensing and DNA replication factor 1*  / reaction / complex






 

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