ENSDARG00000035957


Danio rerio

Features
Gene ID: ENSDARG00000035957
  
Biological name :gmnn
  
Synonyms : geminin, DNA replication inhibitor / gmnn
  
Possible biological names infered from orthology : geminin / O75496 / O88513
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 31541607
Gene end: 31592425
  
Corresponding Affymetrix probe sets: Dr.14739.1.S1_at (Zebrafish Array)   NM_200086_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000125661
Ensembl peptide - ENSDARP00000052184
Ensembl peptide - ENSDARP00000116365
Ensembl peptide - ENSDARP00000154434
NCBI entrez gene - 368320     See in Manteia.
RefSeq - NM_200086
RefSeq Peptide - NP_956380
swissprot - I3IRZ9
swissprot - Q1LU98
ZFIN ID - ZDB-GENE-030429-30
Ensembl - ENSDARG00000035957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GMNNENSGALG00000013626Gallus gallus
 GMNNENSG00000112312Homo sapiens
 GmnnENSMUSG00000006715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CU633857.1 / Danio rerio multiciliate differentiation and DNA synthesis associated cell cycle protein (mcidas), mRNA. / D6RGH6* / MCIDAS* / multiciliate differentiation and DNA synthesis as...ENSDARG0000011531510


Protein motifs (from Interpro)
Interpro ID Name
 IPR022786  Geminin/Multicilin
 IPR029697  Geminin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IMP
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0071910 determination of liver left/right asymmetry IMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
CDT1 association with the CDC6:ORC:origin complex
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle malformed , abnormal
Kupffers vesicle cilium decreased amount , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
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 ZFA:0000107 eye eye decreased distance eye , abnormal
eye fused with eye , abnormal
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 ZFA:0000114 heart heart mislocalised radially , abnormal
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 ZFA:0000117 hypoblast hypoblast decreased thickness , abnormal
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 ZFA:0000123 liver liver mislocalised radially , abnormal
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 ZFA:0000132 neural plate neural plate morphology , abnormal
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 ZFA:0000140 pancreas pancreas mislocalised radially , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type Kupffers vesicle , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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