ENSDARG00000051854


Danio rerio

Features
Gene ID: ENSDARG00000051854
  
Biological name :cdt1
  
Synonyms : cdt1 / chromatin licensing and DNA replication factor 1
  
Possible biological names infered from orthology : DNA replication factor Cdt1 / Q8R4E9 / Q9H211
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 55518519
Gene end: 55530612
  
Corresponding Affymetrix probe sets: Dr.1019.1.A1_at (Zebrafish Array)   XM_690072_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000124390
Ensembl peptide - ENSDARP00000089247
NCBI entrez gene - 566787     See in Manteia.
RefSeq - XM_690072
swissprot - F8W3F6
swissprot - E7F2R5
ZFIN ID - ZDB-GENE-070111-1
Ensembl - ENSDARG00000051854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDT1ENSGALG00000013784Gallus gallus
 CDT1ENSG00000167513Homo sapiens
 Cdt1ENSMUSG00000006585Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011991  ArsR-like helix-turn-helix domain
 IPR014939  CDT1 Geminin-binding domain-like
 IPR032054  DNA replication factor Cdt1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000076 DNA replication checkpoint IBA
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006260 DNA replication IBA
 biological_processGO:0030174 regulation of DNA-dependent DNA replication initiation IBA
 biological_processGO:0051276 chromosome organization IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000092 axis axis increased length , abnormal
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 ZFA:0000117 hypoblast hypoblast apoptotic , abnormal
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 ZFA:0001094 whole organism whole organism cell polyploid , abnormal
whole organism cell tetraploid , abnormal
whole organism cell endopolyploid , abnormal
Show

 ZFA:0009000 cell cell increased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / reaction
 ENSDARG00000045815 mcm10 / Q5RHY1 / minichromosome maintenance 10 replication initiation factor / Q0VBD2* / Q7L590*  / complex / reaction






 

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