ENSMUSG00000026669


Mus musculus

Features
Gene ID: ENSMUSG00000026669
  
Biological name :Mcm10
  
Synonyms : Mcm10 / minichromosome maintenance 10 replication initiation factor / Q0VBD2
  
Possible biological names infered from orthology : Q7L590
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 4989714
Gene end: 5012791
  
Corresponding Affymetrix probe sets: 10479811 (MoGene1.0st)   1433407_at (Mouse Genome 430 2.0 Array)   1433408_a_at (Mouse Genome 430 2.0 Array)   1454244_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027980
Ensembl peptide - ENSMUSP00000100050
NCBI entrez gene - 70024     See in Manteia.
MGI - MGI:1917274
RefSeq - XM_017319252
RefSeq - NM_001305259
RefSeq - NM_027290
RefSeq Peptide - NP_081566
RefSeq Peptide - NP_001292188
swissprot - Q0VBD2
Ensembl - ENSMUSG00000026669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm10ENSDARG00000045815Danio rerio
 MCM10ENSGALG00000034198Gallus gallus
 MCM10ENSG00000065328Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015408  Zinc finger, Mcm10/DnaG-type
 IPR015411  Replication factor Mcm10, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0008283 cell proliferation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0031298 replication fork protection complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004963 abnormal blastocoele morphology "any structural anomaly the fluid-filled cavity of the blastocyst of the preimplantation embryo of mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000029283 Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*  / reaction / complex
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / complex / reaction
 ENSMUSG00000002297 A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*  / reaction / complex
 ENSMUSG00000000028 Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*  / complex / reaction
 ENSMUSG00000006585 Cdt1 / Q8R4E9 / DNA replication factor Cdt1 / Q9H211* / chromatin licensing and DNA replication factor 1*  / reaction / complex
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

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