ENSG00000065328


Homo sapiens

Features
Gene ID: ENSG00000065328
  
Biological name :MCM10
  
Synonyms : MCM10 / minichromosome maintenance 10 replication initiation factor / Q7L590
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p13
Gene start: 13161554
Gene end: 13211104
  
Corresponding Affymetrix probe sets: 220651_s_at (Human Genome U133 Plus 2.0 Array)   222962_s_at (Human Genome U133 Plus 2.0 Array)   223570_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418268
Ensembl peptide - ENSP00000367966
Ensembl peptide - ENSP00000367986
Ensembl peptide - ENSP00000417094
NCBI entrez gene - 55388     See in Manteia.
OMIM - 609357
RefSeq - XM_011519538
RefSeq - NM_018518
RefSeq - NM_182751
RefSeq Peptide - NP_060988
RefSeq Peptide - NP_877428
swissprot - Q5T670
swissprot - Q7L590
swissprot - C9J600
Ensembl - ENSG00000065328
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm10ENSDARG00000045815Danio rerio
 MCM10ENSGALG00000034198Gallus gallus
 Mcm10ENSMUSG00000026669Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015408  Zinc finger, Mcm10/DnaG-type
 IPR015411  Replication factor Mcm10, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0008283 cell proliferation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0031298 replication fork protection complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000097046 CDC7 / O00311 / cell division cycle 7  / reaction / complex
 ENSG00000006634 DBF4 / Q9UBU7 / DBF4 zinc finger  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000093009 CDC45 / O75419 / cell division cycle 45  / reaction / complex
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000167513 CDT1 / Q9H211 / chromatin licensing and DNA replication factor 1  / reaction / complex
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / complex / reaction
 ENSG00000092853 CLSPN / Q9HAW4 / claspin  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000204086 RPA4 / Q13156 / replication protein A4  / complex / reaction






 

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