ENSG00000092853


Homo sapiens

Features
Gene ID: ENSG00000092853
  
Biological name :CLSPN
  
Synonyms : claspin / CLSPN / Q9HAW4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.3
Gene start: 35720218
Gene end: 35769967
  
Corresponding Affymetrix probe sets: 1553120_at (Human Genome U133 Plus 2.0 Array)   219621_at (Human Genome U133 Plus 2.0 Array)   242150_at (Human Genome U133 Plus 2.0 Array)   243840_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428848
Ensembl peptide - ENSP00000251195
Ensembl peptide - ENSP00000312995
Ensembl peptide - ENSP00000362317
NCBI entrez gene - 63967     See in Manteia.
OMIM - 605434
RefSeq - XM_011541941
RefSeq - NM_001190481
RefSeq - NM_001330490
RefSeq - NM_022111
RefSeq - XM_011541938
RefSeq - XM_011541939
RefSeq - XM_011541940
RefSeq Peptide - NP_001177410
RefSeq Peptide - NP_001317419
RefSeq Peptide - NP_071394
swissprot - Q9HAW4
swissprot - E7ESG2
Ensembl - ENSG00000092853
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLSPNENSGALG00000002346Gallus gallus
 ClspnENSMUSG00000042489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024146  Claspin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IDA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0033314 mitotic DNA replication checkpoint IMP
 biological_processGO:0097194 execution phase of apoptosis TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0010997 anaphase-promoting complex binding IPI


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Activation of ATR in response to replication stress
Ub-specific processing proteases
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000048028 USP28 / Q96RU2 / ubiquitin specific peptidase 28  / complex
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / complex / reaction
 ENSG00000111602 Q9UNS1 / TIMELESS / timeless circadian regulator  / reaction
 ENSG00000149554 CHEK1 / O14757 / checkpoint kinase 1  / reaction
 ENSG00000097046 CDC7 / O00311 / cell division cycle 7  / complex / reaction
 ENSG00000006634 DBF4 / Q9UBU7 / DBF4 zinc finger  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000075131 TIPIN / Q9BVW5 / TIMELESS interacting protein  / reaction
 ENSG00000093009 CDC45 / O75419 / cell division cycle 45  / reaction / complex
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction
 ENSG00000165806 CASP7 / P55210 / caspase 7  / reaction
 ENSG00000065328 MCM10 / Q7L590 / minichromosome maintenance 10 replication initiation factor  / complex / reaction






 

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