ENSG00000048028


Homo sapiens

Features
Gene ID: ENSG00000048028
  
Biological name :USP28
  
Synonyms : Q96RU2 / ubiquitin specific peptidase 28 / USP28
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q23.2
Gene start: 113797874
Gene end: 113875570
  
Corresponding Affymetrix probe sets: 1552678_a_at (Human Genome U133 Plus 2.0 Array)   230623_x_at (Human Genome U133 Plus 2.0 Array)   231837_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445743
Ensembl peptide - ENSP00000445722
Ensembl peptide - ENSP00000446284
Ensembl peptide - ENSP00000003302
Ensembl peptide - ENSP00000437450
Ensembl peptide - ENSP00000437688
Ensembl peptide - ENSP00000438050
Ensembl peptide - ENSP00000440260
Ensembl peptide - ENSP00000440799
Ensembl peptide - ENSP00000441513
Ensembl peptide - ENSP00000442257
Ensembl peptide - ENSP00000442431
Ensembl peptide - ENSP00000444991
NCBI entrez gene - 57646     See in Manteia.
OMIM - 610748
RefSeq - XM_017018069
RefSeq - XM_005271636
RefSeq - XM_005271637
RefSeq - XM_005271638
RefSeq - XM_005271639
RefSeq - XM_011542936
RefSeq - XM_011542938
RefSeq - XM_011542941
RefSeq - XM_011542942
RefSeq - XM_017018056
RefSeq - XM_017018057
RefSeq - XM_017018058
RefSeq - XM_017018059
RefSeq - XM_017018060
RefSeq - XM_017018061
RefSeq - XM_017018062
RefSeq - XM_017018063
RefSeq - XM_017018064
RefSeq - XM_017018065
RefSeq - XM_017018066
RefSeq - XM_017018067
RefSeq - XM_017018068
RefSeq - NM_001301029
RefSeq - NM_001346254
RefSeq - NM_001346255
RefSeq - NM_001346257
RefSeq - NM_001346260
RefSeq - NM_001346261
RefSeq - NM_001346273
RefSeq - NM_020886
RefSeq - XM_005271630
RefSeq - XM_005271631
RefSeq - XM_005271632
RefSeq - XM_005271633
RefSeq Peptide - NP_001333184
RefSeq Peptide - NP_001333186
RefSeq Peptide - NP_001333189
RefSeq Peptide - NP_001333190
RefSeq Peptide - NP_001333191
RefSeq Peptide - NP_001333202
RefSeq Peptide - NP_065937
RefSeq Peptide - NP_001287958
RefSeq Peptide - NP_001333183
swissprot - H0YH19
swissprot - Q96RU2
swissprot - B4E3L3
swissprot - F5GZ74
swissprot - F5H2G4
swissprot - F5H6Q3
swissprot - G3V1N5
swissprot - H0YFA0
swissprot - H0YFD7
swissprot - H0YFT9
swissprot - H0YFX3
swissprot - H0YG96
Ensembl - ENSG00000048028
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp28ENSDARG00000008880Danio rerio
 USP28ENSGALG00000006969Gallus gallus
 Usp28ENSMUSG00000032267Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP25 / Q9UHP3 / ubiquitin specific peptidase 25ENSG0000015531350


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR009060  UBA-like superfamily
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000092853 CLSPN / Q9HAW4 / claspin  / complex
 ENSG00000136997 MYC / P01106 / MYC proto-oncogene, bHLH transcription factor  / complex






 

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