ENSG00000155313


Homo sapiens

Features
Gene ID: ENSG00000155313
  
Biological name :USP25
  
Synonyms : Q9UHP3 / ubiquitin specific peptidase 25 / USP25
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q21.1
Gene start: 15730025
Gene end: 15880069
  
Corresponding Affymetrix probe sets: 1555558_at (Human Genome U133 Plus 2.0 Array)   1555559_s_at (Human Genome U133 Plus 2.0 Array)   1563497_at (Human Genome U133 Plus 2.0 Array)   220419_s_at (Human Genome U133 Plus 2.0 Array)   223167_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404086
Ensembl peptide - ENSP00000383044
Ensembl peptide - ENSP00000402354
Ensembl peptide - ENSP00000285679
Ensembl peptide - ENSP00000285681
Ensembl peptide - ENSP00000299574
NCBI entrez gene - 29761     See in Manteia.
OMIM - 604736
RefSeq - XM_017028329
RefSeq - XM_017028321
RefSeq - XM_017028322
RefSeq - XM_017028323
RefSeq - XM_017028324
RefSeq - XM_017028325
RefSeq - XM_017028327
RefSeq - XM_017028328
RefSeq - NM_001283041
RefSeq - NM_001283042
RefSeq - NM_013396
RefSeq - XM_005260949
RefSeq - XM_006723992
RefSeq - XM_011529529
RefSeq - XM_011529531
RefSeq - XM_011529533
RefSeq Peptide - NP_001269970
RefSeq Peptide - NP_001269971
RefSeq Peptide - NP_037528
swissprot - H7C253
swissprot - H7C1T8
swissprot - Q96B65
swissprot - Q9UHP3
Ensembl - ENSG00000155313
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp25ENSDARG00000012314Danio rerio
 USP25ENSGALG00000015693Gallus gallus
 Usp25ENSMUSG00000022867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP28 / Q96RU2 / ubiquitin specific peptidase 28ENSG0000004802848


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR003903  Ubiquitin interacting motif
 IPR009060  UBA-like superfamily
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0070536 protein K63-linked deubiquitination IMP
 biological_processGO:0071108 protein K48-linked deubiquitination IMP
 biological_processGO:1904293 negative regulation of ERAD pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity TAS
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0043130 ubiquitin binding NAS
 molecular_functionGO:0051117 ATPase binding IPI
 molecular_functionGO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway NAS


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex






 

1 s.

 
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