ENSMUSG00000032267


Mus musculus

Features
Gene ID: ENSMUSG00000032267
  
Biological name :Usp28
  
Synonyms : Q5I043 / ubiquitin specific peptidase 28 / Usp28
  
Possible biological names infered from orthology : Q96RU2
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.3
Gene start: 48985375
Gene end: 49042517
  
Corresponding Affymetrix probe sets: 10585099 (MoGene1.0st)   1433982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150707
Ensembl peptide - ENSMUSP00000047467
Ensembl peptide - ENSMUSP00000149207
Ensembl peptide - ENSMUSP00000150005
NCBI entrez gene - 235323     See in Manteia.
MGI - MGI:2442293
RefSeq - XM_011242508
RefSeq - XM_006510262
RefSeq - XM_006510263
RefSeq - XM_006510264
RefSeq - XM_006510265
RefSeq - NM_175482
RefSeq - XM_006510259
RefSeq - XM_006510260
RefSeq - XM_006510261
RefSeq Peptide - NP_780691
swissprot - A0A1L1SUC4
swissprot - A0A1L1SSQ8
swissprot - Q5I043
Ensembl - ENSMUSG00000032267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp28ENSDARG00000008880Danio rerio
 USP28ENSGALG00000006969Gallus gallus
 USP28ENSG00000048028Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp25 / P57080 / ubiquitin specific peptidase 25 / Q9UHP3*ENSMUSG0000002286749


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR009060  UBA-like superfamily
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1.1Pcha/Pkd1+,Pkd2tm1Som/Pkd2tm2Som
Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkd1tm1.1Pcha/Pkd1+,Pkd2tm1Som/Pkd2tm2Som
Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkd1tm1.1Pcha/Pkd1+,Pkd2tm1Som/Pkd2tm2Som
Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022346 Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*  / complex
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / complex






 

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contact: otassy@igbmc.fr