ENSMUSG00000022346


Mus musculus

Features
Gene ID: ENSMUSG00000022346
  
Biological name :Myc
  
Synonyms : Myc / myelocytomatosis oncogene / P01108
  
Possible biological names infered from orthology : MYC proto-oncogene, bHLH transcription factor / P01106
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D1
Gene start: 61985391
Gene end: 61990374
  
Corresponding Affymetrix probe sets: 10424400 (MoGene1.0st)   1424942_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140183
Ensembl peptide - ENSMUSP00000125480
Ensembl peptide - ENSMUSP00000130285
Ensembl peptide - ENSMUSP00000123821
Ensembl peptide - ENSMUSP00000022971
Ensembl peptide - ENSMUSP00000141139
Ensembl peptide - ENSMUSP00000123852
Ensembl peptide - ENSMUSP00000124758
NCBI entrez gene - 17869     See in Manteia.
MGI - MGI:97250
RefSeq - NM_001177354
RefSeq - NM_001177352
RefSeq - NM_001177353
RefSeq - NM_010849
RefSeq Peptide - NP_001170823
RefSeq Peptide - NP_034979
RefSeq Peptide - NP_001170825
RefSeq Peptide - NP_001170824
swissprot - P01108
swissprot - A0A087WSQ0
swissprot - B2RSN1
swissprot - E0CZD1
swissprot - F6PX41
swissprot - F8WID3
Ensembl - ENSMUSG00000022346
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mycaENSDARG00000045695Danio rerio
 mycbENSDARG00000007241Danio rerio
 MYCENSGALG00000033631Gallus gallus
 MYCENSG00000136997Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mycn / P03966 / N-myc proto-onco protein / P04198* / MYCN proto-oncogene, bHLH transcription factor*ENSMUSG0000003716938
Mycs / Q9Z304 / Protein S-Myc ENSMUSG0000004459730
Mycl / P10166 / Protein L-Myc / P12524* / MYCL proto-oncogene, bHLH transcription factor*ENSMUSG0000002865423
Bmyc / Q6P8Z1 / Protein B-Myc ENSMUSG0000004908621


Protein motifs (from Interpro)
Interpro ID Name
 IPR002418  Transcription regulator Myc
 IPR003327  Leucine zipper, Myc
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR012682  Transcription regulator Myc, N-terminal
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000165 MAPK cascade ISS
 biological_processGO:0000320 re-entry into mitotic cell cycle IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001783 B cell apoptotic process IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0002082 regulation of oxidative phosphorylation IEA
 biological_processGO:0002904 positive regulation of B cell apoptotic process IGI
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006338 chromatin remodeling ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006848 pyruvate transport IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007007 inner mitochondrial membrane organization IEA
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0009314 response to radiation IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009812 flavonoid metabolic process IEA
 biological_processGO:0010332 response to gamma radiation ISS
 biological_processGO:0010468 regulation of gene expression ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0016485 protein processing IMP
 biological_processGO:0019087 transformation of host cell by virus IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032204 regulation of telomere maintenance ISS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032986 protein-DNA complex disassembly ISO
 biological_processGO:0035457 cellular response to interferon-alpha IDA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043279 response to alkaloid IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing IEA
 biological_processGO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
 biological_processGO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044752 response to human chorionic gonadotropin IEA
 biological_processGO:0045023 G0 to G1 transition IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045656 negative regulation of monocyte differentiation ISO
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0046722 lactic acid secretion IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation ISS
 biological_processGO:0048147 negative regulation of fibroblast proliferation ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISO
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0051276 chromosome organization ISO
 biological_processGO:0051782 negative regulation of cell division ISS
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0060070 canonical Wnt signaling pathway ISS
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade ISO
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071322 cellular response to carbohydrate stimulus IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071378 cellular response to growth hormone stimulus IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071409 cellular response to cycloheximide IEA
 biological_processGO:0071456 cellular response to hypoxia ISO
 biological_processGO:0071464 cellular response to hydrostatic pressure IEA
 biological_processGO:0071966 fungal-type cell wall polysaccharide metabolic process IEA
 biological_processGO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation IMP
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1901857 positive regulation of cellular respiration IEA
 biological_processGO:1903841 cellular response to arsenite(3-) IEA
 biological_processGO:1903862 positive regulation of oxidative phosphorylation IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1904586 cellular response to putrescine IEA
 biological_processGO:1904620 cellular response to dimethyl sulfoxide IEA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate IEA
 biological_processGO:1990646 cellular response to prolactin IEA
 biological_processGO:1990858 cellular response to lectin IEA
 biological_processGO:1990859 cellular response to endothelin IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process ISO
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus ISS
 biological_processGO:2001171 positive regulation of ATP biosynthetic process IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum ISO
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0044195 nucleoplasmic reticulum ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003729 mRNA binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070491 repressing transcription factor binding ISO
 molecular_functionGO:0070888 E-box binding ISS
 molecular_functionGO:0071074 eukaryotic initiation factor eIF2 binding ISO


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Myctm1Atp/Myctm2.1Atp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myctm2Fwa/Myc+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: LdlrRgsc366/Ldlr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000687 small lymphoid organs "reduced size of lymphatic tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Myctm1Atp/Myctm2.1Atp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Myctm2.1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Myctm1Atp/Myctm2.1Atp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tmprss6m2Btlr/Tmprss6m2Btlr
Genetic Background: C57BL/6J-Tmprss6m2Btlr

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mycntm2.1Nagy/Mycn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myctm1.1Dmlo/Myctm1.1Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

Allelic Composition: Myctm1Slek/Myctm1Slek
Genetic Background: involves: 129

Allelic Composition: Myctm1.1Dlev/Myctm1.1Dlev
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrl

Allelic Composition: Myctm1.1(MYC)Gwbk/Myctm1.1(MYC)Gwbk
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: ApcMin/Apc+,Myctm1Jlc/Myc+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Ightm3Mnz/Igh+,Myctm37Mnz/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002940 variable body spotting "the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Ightm3Mnz/Igh+,Myctm39Mnz/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Ightm3Mnz/Igh+,Myctm37Mnz/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ightm3Mnz/Igh+,Myctm37Mnz/Myc+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Myctm4.1Fwa/Myctm4.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004470 small nasal bone "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mycntm2.1Nagy/Mycn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Myctm2.1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Myctm1Atp/Myctm2.1Atp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: B6.129P2-Myctm1Atp

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0006326 conductive hearing impairment " reduction in the ability to hear due to lesions in the external auditory canal or middle ear" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Myctm1Jlc/Myc+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il15tm1Imx/Il15tm1Imx,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: B6.129P2-Myctm1Atp

Allelic Composition: Il15tm1Imx/Il15+,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15tm1Imx/Il15tm1Imx,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Myctm1Atp/Myctm2.1Atp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0008372 small malleus "reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008375 short manubrium "reduced length of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008376 small manubrium "reduced size of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Ncoa6tm3Jxu/Ncoa6tm3Jxu,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009106 abnormal pancreas size "anomaly in the average size of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009109 decreased pancreas weight "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009143 abnormal pancreatic duct morphology "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009158 absent pancreatic acinar cells "absence of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: B6.129P2-Myctm1Atp

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Myctm1Atp/Myctm1Atp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Myctm1Atp/Myctm1Atp
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Myctm1Atp/Myctm1Atp
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / complex / reaction
 ENSMUSG00000032267 Usp28 / Q5I043 / ubiquitin specific peptidase 28 / Q96RU2*  / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000028640 Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*  / reaction / complex
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000042207 Kdm5b / Q80Y84 / Lysine-specific demethylase 5B / Q9UGL1* / lysine demethylase 5B*  / reaction / complex
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr