ENSMUSG00000028654


Mus musculus

Features
Gene ID: ENSMUSG00000028654
  
Biological name :Mycl
  
Synonyms : Mycl / P10166 / Protein L-Myc
  
Possible biological names infered from orthology : MYCL proto-oncogene, bHLH transcription factor / P12524
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 122995652
Gene end: 123002485
  
Corresponding Affymetrix probe sets: 10507798 (MoGene1.0st)   1422087_at (Mouse Genome 430 2.0 Array)   1422088_at (Mouse Genome 430 2.0 Array)   1434777_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030407
Ensembl peptide - ENSMUSP00000101859
Ensembl peptide - ENSMUSP00000117232
NCBI entrez gene - 16918     See in Manteia.
MGI - MGI:96799
RefSeq - XM_006502821
RefSeq - NM_001303121
RefSeq - NM_008506
RefSeq Peptide - NP_001290050
RefSeq Peptide - NP_032532
swissprot - P10166
swissprot - Q3UIE0
swissprot - B1ARS4
Ensembl - ENSMUSG00000028654
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myclaENSDARG00000006003Danio rerio
 myclbENSDARG00000034956Danio rerio
 MYCLENSGALG00000024047Gallus gallus
 MYCLENSG00000116990Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mycn / P03966 / N-myc proto-onco protein / P04198* / MYCN proto-oncogene, bHLH transcription factor*ENSMUSG0000003716933
Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*ENSMUSG0000002234629
Mycs / Q9Z304 / Protein S-Myc ENSMUSG0000004459728
Bmyc / Q6P8Z1 / Protein B-Myc ENSMUSG0000004908611


Protein motifs (from Interpro)
Interpro ID Name
 IPR002418  Transcription regulator Myc
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR012682  Transcription regulator Myc, N-terminal
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045607 regulation of inner ear auditory receptor cell differentiation IGI
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Mycltm1.1Rne/Mycltm1.1Rne
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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