Manteia

ENSMUSG00000059436

Mus musculus

Features

Gene ID:	ENSMUSG00000059436

Biological name :	Max

Synonyms :	Max / Max protein

Possible biological names infered from orthology :	MYC associated factor X / P61244

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	C3
Gene start:	76937269
Gene end:	76962201

Corresponding Affymetrix probe sets:	10401128 (MoGene1.0st) 1423501_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000106025 Ensembl peptide - ENSMUSP00000151710 Ensembl peptide - ENSMUSP00000151467 Ensembl peptide - ENSMUSP00000080778 NCBI entrez gene - 17187 See in Manteia. MGI - MGI:96921 RefSeq - NM_008558 RefSeq - XM_006515524 RefSeq - XM_006515523 RefSeq - NM_001146176 RefSeq Peptide - NP_001139648 RefSeq Peptide - NP_032584 swissprot - A0A1W2P7P4 swissprot - Q8C4Y1 swissprot - A0A1W2P702 swissprot - B2RS19 Ensembl - ENSMUSG00000059436

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
max	ENSDARG00000024844	Danio rerio
MAX	ENSGALG00000032249	Gallus gallus
MAX	ENSG00000125952	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0009267	cellular response to starvation	IEA
biological_process	GO:0010243	response to organonitrogen compound	IEA
biological_process	GO:0010629	negative regulation of gene expression	IEA
biological_process	GO:0032868	response to insulin	IEA
biological_process	GO:0048678	response to axon injury	IEA
biological_process	GO:0051402	neuron apoptotic process	IEA
biological_process	GO:0060041	retina development in camera-type eye	IEA
biological_process	GO:0071375	cellular response to peptide hormone stimulus	IEA
cellular_component	GO:0000790	nuclear chromatin	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0016605	PML body	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0032993	protein-DNA complex	IEA
cellular_component	GO:0071339	MLL1 complex	IEA
cellular_component	GO:0090575	RNA polymerase II transcription factor complex	IEA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IEA
molecular_function	GO:0046983	protein dimerization activity	IEA
molecular_function	GO:0070888	E-box binding	IEA

Pathways (from Reactome)

Pathway description

Transcriptional Regulation by E2F6

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001675	abnormal ectoderm development	"failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv
MP:0001685	abnormal endoderm development	"failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv
MP:0003890	abnormal embryonic-extraembryonic boundary morphology	"anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv
MP:0012114	absent inner cell mass proliferation		Show Allelic Composition: Nrg1^tm1Lwr/Nrg1⁺ Genetic Background: involves: 129/Sv

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000057469	E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*	/ reaction / complex
ENSMUSG00000013787	Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*	/ reaction / complex
ENSMUSG00000025050	Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*	/ reaction / complex
ENSMUSG00000024325	Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*	/ reaction / complex
ENSMUSG00000022394	P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*	/ reaction / complex
ENSMUSG00000029836	Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*	/ reaction / complex
ENSMUSG00000036893	Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*	/ complex / reaction
ENSMUSG00000033943	Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*	/ complex
ENSMUSG00000026484	Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*	/ complex / reaction
ENSMUSG00000022346	Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*	/ complex
ENSMUSG00000022634	Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*	/ complex / reaction
ENSMUSG00000038482	Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr