ENSMUSG00000026484


Mus musculus

Features
Gene ID: ENSMUSG00000026484
  
Biological name :Rnf2
  
Synonyms : E3 ubiquitin-protein ligase RING2 / Q9CQJ4 / Rnf2
  
Possible biological names infered from orthology : Q99496 / ring finger protein 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G1
Gene start: 151458004
Gene end: 151500955
  
Corresponding Affymetrix probe sets: 10358698 (MoGene1.0st)   1424873_at (Mouse Genome 430 2.0 Array)   1448041_at (Mouse Genome 430 2.0 Array)   1448042_s_at (Mouse Genome 430 2.0 Array)   1448043_x_at (Mouse Genome 430 2.0 Array)   1451519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139676
Ensembl peptide - ENSMUSP00000140896
Ensembl peptide - ENSMUSP00000140594
Ensembl peptide - ENSMUSP00000140299
Ensembl peptide - ENSMUSP00000075476
NCBI entrez gene - 19821     See in Manteia.
MGI - MGI:1101759
RefSeq - XM_006529269
RefSeq - NM_011277
RefSeq Peptide - NP_035407
swissprot - A0A087WQQ3
swissprot - A0A087WRE9
swissprot - Q9CQJ4
swissprot - A0A087WP87
Ensembl - ENSMUSG00000026484
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf2ENSDARG00000010381Danio rerio
 RNF2ENSGALG00000037219Gallus gallus
 RNF2ENSG00000121481Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*ENSMUSG0000002432565


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0009948 anterior/posterior axis specification IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination IGI
 biological_processGO:0035518 histone H2A monoubiquitination ISO
 biological_processGO:0036353 histone H2A-K119 monoubiquitination IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 cellular_componentGO:0000151 ubiquitin ligase complex ISS
 cellular_componentGO:0000791 euchromatin IDA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0001739 sex chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031519 PcG protein complex ISO
 cellular_componentGO:0035102 PRC1 complex ISO
 cellular_componentGO:0071339 MLL1 complex ISO
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0071535 RING-like zinc finger domain binding ISO


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvl/Rnf2tm1Mvl
Genetic Background: involves: 129P2/Ola * 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvl/Rnf2tm1Mvl
Genetic Background: involves: 129P2/Ola * 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2a+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2a+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvl/Rnf2tm1Mvl
Genetic Background: involves: 129P2/Ola * 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2a+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2a+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Rnf2tm1Mvl/Rnf2+
Genetic Background: involves: 129/Ola * FVB

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Nes-cre/ERT2)5-1Kag/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025050 Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*  / complex
 ENSMUSG00000022394 P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*  / complex
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / reaction / complex
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / reaction / complex
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction / complex
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / complex / reaction
 ENSMUSG00000033943 Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*  / reaction / complex
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / complex






 

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