ENSDARG00000010381


Danio rerio

Features
Gene ID: ENSDARG00000010381
  
Biological name :rnf2
  
Synonyms : Q803I4 / ring finger protein 2 / rnf2
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase RING2 / Q99496 / Q9CQJ4
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 23351454
Gene end: 23361933
  
Corresponding Affymetrix probe sets: Dr.24560.1.S1_at (Zebrafish Array)   NM_131213_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000002609
Ensembl peptide - ENSDARP00000149390
Ensembl peptide - ENSDARP00000128022
NCBI entrez gene - 327035     See in Manteia.
RefSeq - NM_131213
RefSeq Peptide - NP_571288
swissprot - A0A0H2UKC6
swissprot - B2GNY0
swissprot - Q803I4
swissprot - X1WCS5
ZFIN ID - ZDB-GENE-030131-5243
Ensembl - ENSDARG00000010381
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RNF2ENSGALG00000037219Gallus gallus
 RNF2ENSG00000121481Homo sapiens
 Rnf2ENSMUSG00000026484Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032330 regulation of chondrocyte differentiation IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0036353 histone H2A-K119 monoubiquitination ISS
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IGI
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0031519 PcG protein complex ISS
 cellular_componentGO:0035102 PRC1 complex ISS
 cellular_componentGO:0071339 MLL1 complex ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000152 retina retina perforate , abnormal
retina intrinsic apoptotic signaling pathway by p53 class mediator increased occurrence , abnormal
retina cell apoptotic , abnormal
Show

 ZFA:0000184 cleithrum cleithrum poorly ossified , abnormal
Show

 ZFA:0000250 opercle opercle poorly ossified , abnormal
Show

 ZFA:0000561 parasphenoid parasphenoid poorly ossified , abnormal
Show

 ZFA:0001106 pharyngeal pouch pharyngeal pouch cellular quality , abnormal
Show

 ZFA:0001114 head head lacks all parts of type Meckels cartilage , abnormal
head lacks all parts of type neurocranial trabecula , abnormal
head lacks all parts of type palatoquadrate cartilage , abnormal
head lacks all parts of type ceratohyal cartilage , abnormal
head lacks all parts of type ethmoid cartilage , abnormal
head lacks all parts of type hyosymplectic cartilage , abnormal
head lacks all parts of type sternohyoid , abnormal
head lacks all parts of type adductor mandibulae , abnormal
head lacks all parts of type interhyoideus , abnormal
head lacks all parts of type hyohyoideus , abnormal
head lacks all parts of type ventral intermandibularis anterior , abnormal
head lacks all parts of type ventral intermandibularis posterior , abnormal
head lacks all parts of type parachordal cartilage , abnormal
Show

 ZFA:0001115 trunk trunk apoptotic , abnormal
Show

 ZFA:0001117 post-vent region post-vent region apoptotic , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin absent , abnormal
pectoral fin lacks all parts of type scapulocoracoid , abnormal
pectoral fin lacks all parts of type mesocoracoid cartilage , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch apoptotic , abnormal
pharyngeal arch chondrocyte undifferentiated , abnormal
Show

 ZFA:0001321 neurocranial trabecula neurocranial trabecula chondrocyte undifferentiated , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage poorly ossified , abnormal
Show

 ZFA:0001651 sternohyoid sternohyoid decreased size , abnormal
Show

 ZFA:0009091 melanocyte melanocyte increased branchiness , abnormal
Show

 ZFA:0009198 xanthophore xanthophore decreased size , abnormal
xanthophore decreased branchiness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003860 cbx3a / chromobox homolog 3a (HP1 gamma homolog, Drosophila) / CBX3* / Q13185* / chromobox 3*  / reaction / complex
 ENSDARG00000008119 si:ch211-195d17.2 / E2F6* / O54917* / O75461* / E2F transcription factor 6* / Transcription factor E2F6 *  / complex / reaction
 ENSDARG00000024844 max / myc associated factor X / P61244* / Max protein*  / reaction / complex
 ENSDARG00000015966 yaf2 / YY1 associated factor 2 / Q8IY57* / Q99LW6*  / complex
 ENSDARG00000056079 l3mbtl2 / l(3)mbt-like 2 (Drosophila) / P59178* / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit* / Lethal(3)malignant brain tumor-like protein 2 *  / complex
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / reaction / complex
 ENSDARG00000069681 pcgf6 / polycomb group ring finger 6 / Q99NA9* / Q9BYE7* / Polycomb group RING finger protein 6 *  / complex
 ENSDARG00000092158 cbx3b / chromobox homolog 3b / CBX3* / Q13185* / chromobox 3* / chromobox protein homolog 3 *  / complex / reaction






 

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