ENSMUSG00000057469


Mus musculus

Features
Gene ID: ENSMUSG00000057469
  
Biological name :E2f6
  
Synonyms : E2f6 / O54917 / Transcription factor E2F6
  
Possible biological names infered from orthology : E2F transcription factor 6 / O75461
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 16810963
Gene end: 16839742
  
Corresponding Affymetrix probe sets: 10394690 (MoGene1.0st)   1437914_at (Mouse Genome 430 2.0 Array)   1448835_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152576
Ensembl peptide - ENSMUSP00000152882
Ensembl peptide - ENSMUSP00000020908
Ensembl peptide - ENSMUSP00000152314
NCBI entrez gene - 50496     See in Manteia.
MGI - MGI:1354159
RefSeq - XM_006515147
RefSeq - XM_006515148
RefSeq - XM_006515149
RefSeq - NM_033270
RefSeq Peptide - NP_150373
swissprot - O54917
swissprot - A0A1Y7VJU3
swissprot - A0A1Y7VP85
swissprot - Q8K455
Ensembl - ENSMUSG00000057469
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-195d17.2ENSDARG00000008119Danio rerio
 E2F6ENSGALG00000016454Gallus gallus
 E2F6ENSG00000169016Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2f3 / O35261 / Transcription factor E2F3 / O00716* / E2F transcription factor 3*ENSMUSG0000001647745
E2f2 / P56931 / Transcription factor E2F2 / Q14209* / E2F transcription factor 2*ENSMUSG0000001898341
E2f1 / Q61501 / Transcription factor E2F1 / Q01094* / E2F transcription factor 1*ENSMUSG0000002749038
E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*ENSMUSG0000001485929
E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*ENSMUSG0000002755228


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR015635  Transcription factor E2F6
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IGI
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005662 DNA replication factor A complex IC
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltahlb382/Ltahlb382
Genetic Background: C57BL/6J-Ltahlb382/J

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1+,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1+,E2f6tm1Lees/E2f6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)

Allelic Composition: E2f6tm1Sgau/E2f6+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: E2f6tm1Lees/E2f6+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1+,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1+,E2f6tm1Lees/E2f6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snrpntm2Cbr/Snrpn+
Genetic Background: either: B6.Cg-Snrpntm2Cbr or (involves: 129S1/Sv * C57BL/6J * DBA/2J)

Allelic Composition: E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: E2f6tm1Lees/E2f6+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1+,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1+,E2f6tm1Lees/E2f6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,E2f6tm1Lees/E2f6tm1Lees
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex / reaction
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / complex / reaction
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000033943 Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*  / reaction / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / reaction / complex
 ENSMUSG00000024240 Epc1 / Q8C9X6 / Enhancer of polycomb homolog 1 / Q9H2F5*  / complex / reaction
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / complex / reaction
 ENSMUSG00000025050 Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*  / complex / reaction
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / reaction / complex
 ENSMUSG00000022394 P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*  / reaction / complex
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / reaction
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / reaction / complex
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / complex / reaction
 ENSMUSG00000026484 Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*  / reaction / complex
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex






 

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