ENSMUSG00000027552


Mus musculus

Features
Gene ID: ENSMUSG00000027552
  
Biological name :E2f5
  
Synonyms : E2f5 / Q61502 / Transcription factor E2F5
  
Possible biological names infered from orthology : E2F transcription factor 5 / Q15329
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A1
Gene start: 14578641
Gene end: 14606309
  
Corresponding Affymetrix probe sets: 10490894 (MoGene1.0st)   1417444_at (Mouse Genome 430 2.0 Array)   1447625_at (Mouse Genome 430 2.0 Array)   1460207_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127877
Ensembl peptide - ENSMUSP00000029069
NCBI entrez gene - 13559     See in Manteia.
MGI - MGI:105091
RefSeq - NM_007892
RefSeq - XM_006530051
RefSeq Peptide - NP_031918
swissprot - E9Q011
swissprot - Q61502
Ensembl - ENSMUSG00000027552
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f5ENSDARG00000038812Danio rerio
 E2F5ENSGALG00000038915Gallus gallus
 E2F5ENSG00000133740Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*ENSMUSG0000001485963
E2f2 / P56931 / Transcription factor E2F2 / Q14209* / E2F transcription factor 2*ENSMUSG0000001898335
E2f3 / O35261 / Transcription factor E2F3 / O00716* / E2F transcription factor 3*ENSMUSG0000001647732
E2f1 / Q61501 / Transcription factor E2F1 / Q01094* / E2F transcription factor 1*ENSMUSG0000002749031
E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*ENSMUSG0000005746922


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR028316  Transcription factor E2F5
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001893 non-obstructive hydrocephaly "abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004728 abnormal efferent ductules of testis "any structural abnormality in the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: E2f4tm2.1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0006423 dilated rete testis "an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: E2f4tm2.1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0009257 dilated seminiferous tubules "the luminal space of the seminiferous tubules is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv

Allelic Composition: E2f4tm1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0030316 enlarged neurocranium "increased size of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / reaction / complex






 

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