ENSMUSG00000027490


Mus musculus

Features
Gene ID: ENSMUSG00000027490
  
Biological name :E2f1
  
Synonyms : E2f1 / Q61501 / Transcription factor E2F1
  
Possible biological names infered from orthology : E2F transcription factor 1 / Q01094
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 154559407
Gene end: 154569892
  
Corresponding Affymetrix probe sets: 10488785 (MoGene1.0st)   1417878_at (Mouse Genome 430 2.0 Array)   1431875_a_at (Mouse Genome 430 2.0 Array)   1447840_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000894
Ensembl peptide - ENSMUSP00000099434
NCBI entrez gene - 13555     See in Manteia.
MGI - MGI:101941
RefSeq - NM_007891
RefSeq - NM_001291105
RefSeq Peptide - NP_001278034
RefSeq Peptide - NP_031917
swissprot - Q547J6
swissprot - Q61501
swissprot - Q9CYB4
Ensembl - ENSMUSG00000027490
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f1ENSDARG00000103868Danio rerio
 E2F1ENSGALG00000003045Gallus gallus
 E2F1ENSG00000101412Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2f3 / O35261 / Transcription factor E2F3 / O00716* / E2F transcription factor 3*ENSMUSG0000001647740
E2f2 / P56931 / Transcription factor E2F2 / Q14209* / E2F transcription factor 2*ENSMUSG0000001898340
E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*ENSMUSG0000001485926
E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*ENSMUSG0000005746924
E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*ENSMUSG0000002755224


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043276 anoikis IDA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0070345 negative regulation of fat cell proliferation IMP
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071466 cellular response to xenobiotic stimulus IDA
 biological_processGO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle ISO
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA
 biological_processGO:1990086 lens fiber cell apoptotic process IDA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035189 Rb-E2F complex IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000040 absent middle ear ossicles "missing small bones of the tympanic cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000091 short premaxilla "reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0000103 nasal bone hypoplasia "reduced cell number in the bone which forms the nasal bridge" [J:53370]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)721Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pvalbtm1(cre)Arbr/Pvalb+,Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f3tm3Lees/E2f3tm3Lees
Genetic Background: either: 129S/Sv-E2f3tm3Lees or (involves: 129S4/SvJae * C57BL/6)

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic Background: 129-E2f3tm1.1Gle

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pvalbtm1(cre)Arbr/Pvalb+,Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Axin1tm4Cos/Axin1tm4Cos,Ctnnb1tm2.1Kem/Ctnnb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

Allelic Composition: E2f1tm1Meg/E2f1+,Phactr4humdy/Phactr4humdy
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001203 skin irradiation sensitivity "increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

 MP:0001272 increased metastatic potential 
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic Background: 129-E2f3tm1.1Gle

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0002163 abnormal gland morphology "abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1tm4Cos/Axin1tm4Cos,Ctnnb1tm2.1Kem/Ctnnb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm5(E2f1)Gle/E2f3tm5(E2f1)Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm4Gle/E2f3tm4Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm1Lees/E2f3+
Genetic Background: involves: 129S2/SvPas

 MP:0003235 abnormal alisphenoid bone morphology "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0003452 abnormal parotid gland morphology "malformation of either of the largest of the major salivary glands situated below and in front of each ear and opening into the parotid duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94478]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003496 thyroid adenoma "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0003869 ectopic cartilage "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0004385 interparietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(ACTB-Edn1)721Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004455 pterygoid bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004461 basisphenoid bone hypoplasia "underdevelopment or reduced size, usually due to reduced cell number, in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)721Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004467 absent zygomatic bone "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tg(ACTB-Edn1)721Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004473 absent nasal bone "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004475 palatine bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004476 absent palatine bone "absence of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tg(ACTB-Edn1)721Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004501 increased incidence of UV-induced tumors "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004596 abnormal mandibular angle morphology "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004869 frontal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone which forms the forehead and roof of the eye orbit" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004871 premaxilla hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the anterior and interior portion of the maxilla" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004872 absent nasal septum "absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0004899 absent squamosal bone "absence of the thin, plate-like part of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004912 absent mandibular coronoid process "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004915 abnormal Reichert s cartilage "any structural abnormality of the cartilage found in the mesenchyme of the second pharyngeal arch in the embryo from which develop the stapes, styloid process, lesser horn and upper part of the body of the hyoid bone; its proximal end gives rise to the stylohyoid ligament" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0005158 ovary hypoplasia "underdeveloped ovaries, usually due to reduced cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78931]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Tg(ACTB-Edn1)721Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0008301 adrenal medulla hyperplasia "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0008382 gonial bone hypoplasia "underdevelopment or reduced size of the investing bone that lies on the surface of the malleus, usually due to reduced cell number" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm1Lees/E2f3+
Genetic Background: involves: 129S2/SvPas

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0009109 decreased pancreas weight "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0009796 abnormal base-excision repair "any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]
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Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0009895 decreased palatine shelf size "reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0009897 decreased maxillary shelf size "reduced size of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010029 abnormal basicranium morphology "any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0010287 increased reproductive system tumor incidence "greater than the expected number of tumors originating in the reproductive system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0010326 malleus hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0010940 abnormal maxillary prominence morphology 
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm2.1Fad/Rb1tm2.1Fad
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Muttm1Cpv/Muttm1Cpv
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: E2f1tm1Njd/E2f1+,E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: E2f1tm1Njd/E2f1+,E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013440 abnormal exorbital lacrimal gland morphology "any structural anomaly of the large exorbital (extra-orbital) lacrimal glands that are located subcutaneously at the anteroventral base of the ear adjacent to the parotid gland" [ISBN:0123813611, MGI:Anna]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013933 short Meckel s cartilage 
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0014166 ectopic cranial bone "the appearance of an extra bone structure at an atypical location in or near the cranium" [MGI:csmith]
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Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030112 zygomatic bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the quadrilateral bone that forms the prominence of the cheek" [MGI:anna]
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Allelic Composition: Hand1tm3Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

 MP:0030122 temporal bone squamous part hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Hand1tm4Abfi/Hand1+,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0030124 middle ear ossicle hypoplasia "underdevelopment or reduced size of the three bones of the middle ear, usually due to reduced cell number" [MGI:anna]
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Allelic Composition: Hand1tm2Eno/Hand1tm4Abfi,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0030300 upper jaw to lower jaw transformation "homeotic transformation of upper jaw (maxillary) elements into lower jaw-like (mandibular) structures" [MGI:anna, PMID:25725491]
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Allelic Composition: Tg(ACTB-Edn1)721Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1398Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / reaction / complex






 

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