ENSMUSG00000014859


Mus musculus

Features
Gene ID: ENSMUSG00000014859
  
Biological name :E2f4
  
Synonyms : E2f4 / Q8R0K9 / Transcription factor E2F4
  
Possible biological names infered from orthology : E2F transcription factor 4 / Q16254
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105297663
Gene end: 105305370
  
Corresponding Affymetrix probe sets: 10574682 (MoGene1.0st)   1451480_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015003
NCBI entrez gene - 104394     See in Manteia.
MGI - MGI:103012
RefSeq - NM_148952
RefSeq Peptide - NP_683754
swissprot - Q8R0K9
Ensembl - ENSMUSG00000014859
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f4ENSDARG00000101578Danio rerio
 E2F4ENSGALG00000001722Gallus gallus
 E2F4ENSG00000205250Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*ENSMUSG0000002755251
E2f2 / P56931 / Transcription factor E2F2 / Q14209* / E2F transcription factor 2*ENSMUSG0000001898331
E2f3 / O35261 / Transcription factor E2F3 / O00716* / E2F transcription factor 3*ENSMUSG0000001647729
E2f1 / Q61501 / Transcription factor E2F1 / Q01094* / E2F transcription factor 1*ENSMUSG0000002749027
E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*ENSMUSG0000005746919


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR028312  Transcription factor E2F4
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IGI
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006884 cell volume homeostasis IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0044458 motile cilium assembly ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0098534 centriole assembly ISS
 biological_processGO:1903251 multi-ciliated epithelial cell differentiation ISS
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000346 broad head "a greater ear- to -ear distance resulting in the appearance of a wide face and a flattened snout" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001400 hyperresponsive "increased reaction to touch" [J:39801]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001867 rhinitis "inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: E2f4tm1Lees/E2f4+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002237 abnormal nasal cavity morphology "any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002244 abnormal turbinate morphology "any structural anomaly of the bony plates of the lateral wall of the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004728 abnormal efferent ductules of testis "any structural abnormality in the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: E2f4tm2.1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006423 dilated rete testis "an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: E2f4tm2.1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009257 dilated seminiferous tubules "the luminal space of the seminiferous tubules is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: E2f4tm1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f4tm1Lees/E2f4+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f4tm1Lees/E2f4+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: C57BL/6

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0013792 abnormal small intestine goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030189 broad snout "increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction / complex
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction






 

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