ENSMUSG00000018983


Mus musculus

Features
Gene ID: ENSMUSG00000018983
  
Biological name :E2f2
  
Synonyms : E2f2 / P56931 / Transcription factor E2F2
  
Possible biological names infered from orthology : E2F transcription factor 2 / Q14209
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 136172394
Gene end: 136196057
  
Corresponding Affymetrix probe sets: 10509168 (MoGene1.0st)   1436434_at (Mouse Genome 430 2.0 Array)   1455790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050047
NCBI entrez gene - 242705     See in Manteia.
MGI - MGI:1096341
RefSeq - NM_177733
RefSeq Peptide - NP_808401
swissprot - P56931
Ensembl - ENSMUSG00000018983
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E2F2ENSDARG00000079233Danio rerio
 E2F2ENSG00000007968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2f3 / O35261 / Transcription factor E2F3 / O00716* / E2F transcription factor 3*ENSMUSG0000001647747
E2f1 / Q61501 / Transcription factor E2F1 / Q01094* / E2F transcription factor 1*ENSMUSG0000002749039
E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*ENSMUSG0000001485929
E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*ENSMUSG0000002755226
E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*ENSMUSG0000005746925


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IEA
 biological_processGO:1990086 lens fiber cell apoptotic process IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDC6 association with the ORC:origin complex
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic Background: 129-E2f3tm1.1Gle

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic Background: 129-E2f3tm1.1Gle

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / complex / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex






 

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