ENSGALG00000001722


Gallus gallus

Features
Gene ID: ENSGALG00000001722
  
Biological name :E2F4
  
Synonyms : E2F4 / E2F transcription factor 4
  
Possible biological names infered from orthology : Q16254 / Q8R0K9 / Transcription factor E2F4
  
Species: Gallus gallus
  
Chr. number: 11
Strand: 1
Band:
Gene start: 1047693
Gene end: 1059631
  
Corresponding Affymetrix probe sets: Gga.3606.1.S1_s_at (Chicken Array)   GgaAffx.12446.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043952
Ensembl peptide - ENSGALP00000002638
NCBI entrez gene - 769430     See in Manteia.
RefSeq - NM_001005835
RefSeq Peptide - NP_001005835
swissprot - Q5ZJU1
swissprot - A0A1D5NUD6
Ensembl - ENSGALG00000001722
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f4ENSDARG00000101578Danio rerio
 E2F4ENSG00000205250Homo sapiens
 E2f4ENSMUSG00000014859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F5 / transcription factor E2F5 / Q15329* / Q61502* / E2F transcription factor 5*ENSGALG0000003891547
E2F3 / E2F transcription factor 3 / O00716* / O35261* / Transcription factor E2F3 *ENSGALG0000001268025
E2F1 / transcription factor E2F1 / Q01094* / Q61501* / E2F transcription factor 1*ENSGALG0000000304524
E2F6 / E2F transcription factor 6 / O54917* / O75461* / Transcription factor E2F6 *ENSGALG0000001645417


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015633  E2F Family
 IPR028312  Transcription factor E2F4
 IPR032198  E2F transcription factor, CC-MB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0002064 epithelial cell development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006884 cell volume homeostasis IEA
 biological_processGO:0008015 blood circulation IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060271 cilium assembly IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / reaction / complex
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction / complex
 ENSGALG00000016823 TFDP1* / TFDP3* / Q5H9I0* / Q08639* / Q14186* / transcription factor Dp-1* / transcription factor Dp family member 3*  / complex
 ENSGALG00000025759 TFDP2 / transcription factor Dp-2 / Q14188*  / complex






 

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