ENSMUSG00000070348


Mus musculus

Features
Gene ID: ENSMUSG00000070348
  
Biological name :Ccnd1
  
Synonyms : Ccnd1 / G1/S-specific cyclin-D1 / P25322
  
Possible biological names infered from orthology : cyclin D1 / P24385
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 144929931
Gene end: 144939925
  
Corresponding Affymetrix probe sets: 10569646 (MoGene1.0st)   1417419_at (Mouse Genome 430 2.0 Array)   1417420_at (Mouse Genome 430 2.0 Array)   1448698_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091495
NCBI entrez gene - 12443     See in Manteia.
MGI - MGI:88313
RefSeq - XM_011241977
RefSeq - NM_007631
RefSeq Peptide - NP_031657
swissprot - P25322
swissprot - Q790L7
Ensembl - ENSMUSG00000070348
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnd1ENSDARG00000101637Danio rerio
 CCND1ENSGALG00000007555Gallus gallus
 CCND1ENSG00000110092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnd2 / P30280 / G1/S-specific cyclin-D2 / P30279* / cyclin D2*ENSMUSG0000000018462
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*ENSMUSG0000003416551
Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*ENSMUSG0000000206823
Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*ENSMUSG0000002821222
Ccna1 / Q61456 / Cyclin-A1 / P78396*ENSMUSG0000002779321
Ccno / P0C242 / Cyclin-O / P22674*ENSMUSG0000004241720
Ccna2 / P51943 / Cyclin-A2 / P20248*ENSMUSG0000002771520
Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*ENSMUSG0000004143118
Ccnb3 / Q8WWL7* / cyclin B3*ENSMUSG0000005159217
Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*ENSMUSG0000003221817


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR015451  Cyclin D
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000320 re-entry into mitotic cell cycle IDA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IGI
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0033327 Leydig cell differentiation IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IGI
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0044321 response to leptin IEA
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0070141 response to UV-A IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0097421 liver regeneration IDA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IGI
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0070064 proline-rich region binding IEA


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
RMTs methylate histone arginines
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Regulation of RUNX1 Expression and Activity
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1+,Tg(MMTVneu)202Mul/0,Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ccnd1tm2(Ccnd2)Pisc/Ccnd1tm2(Ccnd2)Pisc
Genetic Background: involves: 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6J * SJL/J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6J * SJL/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm1(CCNE)Pisc/Ccnd1tm1(CCNE)Pisc
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1+,Tg(MMTVneu)202Mul/0,Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ccnd1tm2(Ccnd2)Pisc/Ccnd1tm2(Ccnd2)Pisc
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ephb2tm1Jf/Ephb2tm1Jf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Sgk3m1Btlr/Sgk3m1Btlr
Genetic Background: C57BL/6J-Sgk3m1Btlr

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1+,Tg(MMTVneu)202Mul/0,Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6J * SJL/J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1smdg/Cacna1smdg
Genetic Background: involves: 129 * STOCK T/t4

Allelic Composition: Ccnd1tm4Pisc/Ccnd1tm4Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm4Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm5.1Pisc/Ccnd1tm5.1Pisc
Genetic Background: Not Specified

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm5.1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm5.1Pisc,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002296 aspiration "inspiration into the airways of fluid or any foreign material " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: C57BL/6J

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm5.1Pisc,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6J * SJL/J

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0004831 long incisors "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ccnd1tm2(Ccnd2)Pisc/Ccnd1tm2(Ccnd2)Pisc
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm1(CCNE)Pisc/Ccnd1tm1(CCNE)Pisc
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccnd1tm1(CCNE)Pisc/Ccnd1tm1(CCNE)Pisc
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008509 disorganized retinal ganglion layer "derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009718 absent Purkinje cell layer "there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Tg(MMTV-tTA)25755Kuw/0,Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Tg(MMTVneu)202Mul/0,Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Tg(MMTV-tTA)25755Kuw/0,Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Tg(MMTV-tTA)25755Kuw/0,Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Tg(MMTV-tTA)25755Kuw/0,Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ccnd1tm1Wbg/Ccnd1+,Tg(MMTVneu)202Mul/0,Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Tg(MMTVneu)202Mul/0,Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ccnd1tm1Wbg/Ccnd1+,Tg(MMTVneu)202Mul/0,Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0030541 misaligned incisors "abnormal alignment of the upper and lower incisor teeth, usually resulting in malocclusion; in gnawing rodents, where incisors are rootless and grow continually, signs of incisor malocclusion include uneven wear patterns, sloping of the cutting edges, fractured teeth, altered pigmentation, and obvious pathological overgrowth of the incisors" [HP:0011062, https://books.google.com/books?isbn=0323394302, PMID:19622764]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / complex / reaction
 ENSMUSG00000026313 Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*  / complex / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000000561 Wdr77 / Q99J09 / WD repeat domain 77 / Q9BQA1*  / complex
 ENSMUSG00000023110 Prmt5 / protein arginine N-methyltransferase 5 / O14744* / protein arginine methyltransferase 5*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000021103 Mnat1 / P51949 / CDK-activating kinase assembly factor MAT1 / P51948* / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSMUSG00000024335 Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*  / reaction / complex
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex / reaction
 ENSMUSG00000021548 Ccnh / Q61458 / Cyclin-H / P51946*  / reaction
 ENSMUSG00000031458 Coprs / Q9CQ13 / Coordinator of PRMT5 and differentiation stimulator / Q9NQ92*  / complex / reaction
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / reaction
 ENSMUSG00000040274 Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*  / complex / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction
 ENSMUSG00000069089 Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*  / reaction






 

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