ENSMUSG00000026313


Mus musculus

Features
Gene ID: ENSMUSG00000026313
  
Biological name :Hdac4
  
Synonyms : Hdac4 / Histone deacetylase 4 / Q6NZM9
  
Possible biological names infered from orthology : P56524
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 91928779
Gene end: 92195699
  
Corresponding Affymetrix probe sets: 10356626 (MoGene1.0st)   10356628 (MoGene1.0st)   1436758_at (Mouse Genome 430 2.0 Array)   1447566_at (Mouse Genome 430 2.0 Array)   1454693_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141018
Ensembl peptide - ENSMUSP00000008995
Ensembl peptide - ENSMUSP00000095249
Ensembl peptide - ENSMUSP00000140092
NCBI entrez gene - 208727     See in Manteia.
MGI - MGI:3036234
RefSeq - XM_017319501
RefSeq - XM_017319486
RefSeq - XM_017319487
RefSeq - XM_017319488
RefSeq - XM_017319498
RefSeq - NM_207225
RefSeq - XM_006529311
RefSeq - XM_006529312
RefSeq - XM_006529313
RefSeq - XM_006529314
RefSeq - XM_006529315
RefSeq - XM_017319476
RefSeq - XM_017319477
RefSeq - XM_017319478
RefSeq - XM_017319479
RefSeq - XM_017319480
RefSeq - XM_017319482
RefSeq Peptide - NP_997108
swissprot - A0A087WSF0
swissprot - A0A087WQ92
swissprot - Q6NZM9
Ensembl - ENSMUSG00000026313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac4ENSDARG00000098349Danio rerio
 HDAC4ENSGALG00000004288Gallus gallus
 HDAC4ENSG00000068024Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac5 / histone deacetylase 5 isoform 4 / Q9UQL6* / histone deacetylase 5*ENSMUSG0000000885560
Hdac7 / Q8C2B3 / Histone deacetylase 7 / Q8WUI4*ENSMUSG0000002247545
Hdac9 / histone deacetylase 9 / Q9UKV0*ENSMUSG0000000469827
Hdac6 / Q9Z2V5 / Histone deacetylase 6 / Q9UBN7*ENSMUSG0000003116125
Hdac10 / Q6P3E7 / Histone deacetylase 10 / Q969S8*ENSMUSG0000006290611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR017320  Histone deacetylase class II, eukaryotic
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR024643  Histone deacetylase, glutamine rich N-terminal domain
 IPR033660  Histone deacetylase 4
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0002076 osteoblast development IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010832 negative regulation of myotube differentiation ISO
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IMP
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IMP
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016575 histone deacetylation ISO
 biological_processGO:0033235 positive regulation of protein sumoylation ISO
 biological_processGO:0034983 peptidyl-lysine deacetylation ISO
 biological_processGO:0040029 regulation of gene expression, epigenetic ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043393 regulation of protein binding ISO
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045820 negative regulation of glycolytic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048742 regulation of skeletal muscle fiber development IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051153 regulation of striated muscle cell differentiation IGI
 biological_processGO:0070555 response to interleukin-1 ISO
 biological_processGO:0070932 histone H3 deacetylation ISO
 biological_processGO:0070933 histone H4 deacetylation ISO
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071374 cellular response to parathyroid hormone stimulus IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IEA
 cellular_componentGO:0000118 histone deacetylase complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 cellular_componentGO:0030017 sarcomere ISO
 cellular_componentGO:0030018 Z disc ISO
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0031672 A band ISO
 cellular_componentGO:0042641 actomyosin IDA
 molecular_functionGO:0001047 core promoter binding ISO
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IGI
 molecular_functionGO:0004407 histone deacetylase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030955 potassium ion binding ISO
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity ISO
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding ISO
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000440 domed skull 
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001994 increased blinking frequency 
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003417 premature endochondral bone ossification "early onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004243 abnormal motor nerve terminal sprouting "aberrant response of a motor neuron to form new neuritic processes (sprouts) that emerge from the nodes of Ranvier or terminal arborizations in response to nerve injury (such as denervation), application of nerve toxin, or muscle inactivity (usually due to disease)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac4tm1Eno/Hdac4+,Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9+
Genetic Background: involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0006432 abnormal costal cartilage morphology "any structural anomaly of the nonvascular, resilient, flexible connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the costal cartilage above" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac4tm1Eno/Hdac4tm2.1Eno,Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * 129S/SvEv * 129S2/SvPas

Allelic Composition: Hdac4tm1Eno/Hdac4+,Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9+
Genetic Background: involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0030356 premature lambdoid suture closure "early closure of the lambdoid suture of the skull" [MGI:anna]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000024335 Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*  / reaction / complex
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / reaction / complex






 

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