ENSMUSG00000031161


Mus musculus

Features
Gene ID: ENSMUSG00000031161
  
Biological name :Hdac6
  
Synonyms : Hdac6 / Histone deacetylase 6 / Q9Z2V5
  
Possible biological names infered from orthology : Q9UBN7
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 7930120
Gene end: 7947889
  
Corresponding Affymetrix probe sets: 10603387 (MoGene1.0st)   1448928_at (Mouse Genome 430 2.0 Array)   1458968_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120348
Ensembl peptide - ENSMUSP00000123482
Ensembl peptide - ENSMUSP00000121653
Ensembl peptide - ENSMUSP00000033501
Ensembl peptide - ENSMUSP00000111306
NCBI entrez gene - 15185     See in Manteia.
MGI - MGI:1333752
RefSeq - XM_017318388
RefSeq - XM_006527567
RefSeq - XM_017318389
RefSeq - NM_001130416
RefSeq - NM_010413
RefSeq - XM_017318390
RefSeq Peptide - NP_034543
RefSeq Peptide - NP_001123888
swissprot - Q9Z2V5
swissprot - B1AUA9
swissprot - A0A1B0GX25
swissprot - B1AUA8
Ensembl - ENSMUSG00000031161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac6ENSDARG00000008384Danio rerio
 HDAC6ENSG00000094631Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*ENSMUSG0000002631323
Hdac10 / Q6P3E7 / Histone deacetylase 10 / Q969S8*ENSMUSG0000006290623
Hdac5 / histone deacetylase 5 isoform 4 / Q9UQL6* / histone deacetylase 5*ENSMUSG0000000885521
Hdac7 / Q8C2B3 / Histone deacetylase 7 / Q8WUI4*ENSMUSG0000002247520
Hdac9 / histone deacetylase 9 / Q9UKV0*ENSMUSG000000046986


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006515 protein quality control for misfolded or incompletely synthesized proteins IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007026 negative regulation of microtubule depolymerization IDA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0016241 regulation of macroautophagy IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032418 lysosome localization IEA
 biological_processGO:0032461 positive regulation of protein oligomerization IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IMP
 biological_processGO:0035967 cellular response to topologically incorrect protein IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0043242 negative regulation of protein complex disassembly IEA
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0048668 collateral sprouting IMP
 biological_processGO:0051646 mitochondrion localization IMP
 biological_processGO:0051788 response to misfolded protein IEA
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0070201 regulation of establishment of protein localization IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070842 aggresome assembly IEA
 biological_processGO:0070845 polyubiquitinated misfolded protein transport IEA
 biological_processGO:0070846 Hsp90 deacetylation IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0071218 cellular response to misfolded protein IMP
 biological_processGO:0090035 positive regulation of chaperone-mediated protein complex assembly IEA
 biological_processGO:0090042 tubulin deacetylation IEA
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IGI
 biological_processGO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004407 histone deacetylase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0042903 tubulin deacetylase activity IMP
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IDA
 molecular_functionGO:0051787 misfolded protein binding ISO
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
HSF1 activation
Cilium Assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hdac6tm1.1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hdac6tm1.1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hdac6tm1.1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hdac6tm1.1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif1atm1Tcrl/Eif1a+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Cacna1atg/Cacna1atm2.1Maag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * FVB/N

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1atg/Cacna1atm2.1Maag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * FVB/N

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hdac6tm1.1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex






 

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