ENSMUSG00000008855


Mus musculus

Features
Gene ID: ENSMUSG00000008855
  
Biological name :Hdac5
  
Synonyms : Hdac5 / histone deacetylase 5 isoform 4
  
Possible biological names infered from orthology : histone deacetylase 5 / Q9UQL6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 102194432
Gene end: 102230166
  
Corresponding Affymetrix probe sets: 10391577 (MoGene1.0st)   10338195 (MoGene1.0st)   10338237 (MoGene1.0st)   10338322 (MoGene1.0st)   10338605 (MoGene1.0st)   10338738 (MoGene1.0st)   10338751 (MoGene1.0st)   10339192 (MoGene1.0st)   10339241 (MoGene1.0st)   10339553 (MoGene1.0st)   10339877 (MoGene1.0st)   10340092 (MoGene1.0st)   10340380 (MoGene1.0st)   10341127 (MoGene1.0st)   10341271 (MoGene1.0st)   10341480 (MoGene1.0st)   10341765 (MoGene1.0st)   10341901 (MoGene1.0st)   10341992 (MoGene1.0st)   10342156 (MoGene1.0st)   10342964 (MoGene1.0st)   10342969 (MoGene1.0st)   10343097 (MoGene1.0st)   10343251 (MoGene1.0st)   10343565 (MoGene1.0st)   10343803 (MoGene1.0st)   10343808 (MoGene1.0st)   10343813 (MoGene1.0st)   10343907 (MoGene1.0st)   10343941 (MoGene1.0st)   10344219 (MoGene1.0st)   10344281 (MoGene1.0st)   10344528 (MoGene1.0st)   10338098 (MoGene1.0st)   10338169 (MoGene1.0st)   10338202 (MoGene1.0st)   10338219 (MoGene1.0st)   10338282 (MoGene1.0st)   10338346 (MoGene1.0st)   10338726 (MoGene1.0st)   10338993 (MoGene1.0st)   10339035 (MoGene1.0st)   10339239 (MoGene1.0st)   10339294 (MoGene1.0st)   10339300 (MoGene1.0st)   10339317 (MoGene1.0st)   10339322 (MoGene1.0st)   10339353 (MoGene1.0st)   10339401 (MoGene1.0st)   10339504 (MoGene1.0st)   10339798 (MoGene1.0st)   10340283 (MoGene1.0st)   10340522 (MoGene1.0st)   10340532 (MoGene1.0st)   10340610 (MoGene1.0st)   10340616 (MoGene1.0st)   10341625 (MoGene1.0st)   10341942 (MoGene1.0st)   10342029 (MoGene1.0st)   10342235 (MoGene1.0st)   10342382 (MoGene1.0st)   10342518 (MoGene1.0st)   10342730 (MoGene1.0st)   10343432 (MoGene1.0st)   10343809 (MoGene1.0st)   10344276 (MoGene1.0st)   10344530 (MoGene1.0st)   10344589 (MoGene1.0st)   1415743_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102768
Ensembl peptide - ENSMUSP00000008999
Ensembl peptide - ENSMUSP00000102769
Ensembl peptide - ENSMUSP00000118108
Ensembl peptide - ENSMUSP00000116672
Ensembl peptide - ENSMUSP00000116646
Ensembl peptide - ENSMUSP00000115435
Ensembl peptide - ENSMUSP00000102770
NCBI entrez gene - 15184     See in Manteia.
MGI - MGI:1333784
RefSeq - XM_017314282
RefSeq - NM_001284248
RefSeq - NM_001284249
RefSeq - NM_001284250
RefSeq - NM_010412
RefSeq - XM_006532254
RefSeq - XM_011248747
RefSeq - XM_011248748
RefSeq - XM_011248749
RefSeq - XM_011248750
RefSeq - XM_011248752
RefSeq - XM_011248754
RefSeq - XM_011248755
RefSeq - XM_017314281
RefSeq - NM_001077696
RefSeq Peptide - NP_001271177
RefSeq Peptide - NP_001271178
RefSeq Peptide - NP_001271179
RefSeq Peptide - NP_034542
RefSeq Peptide - NP_001071164
swissprot - B7ZDF3
swissprot - Q3UJF1
swissprot - A2AWS5
swissprot - D6RH93
swissprot - B7ZDF7
swissprot - B7ZDF6
swissprot - B7ZDF5
swissprot - B7ZDF4
Ensembl - ENSMUSG00000008855
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac5ENSDARG00000075139Danio rerio
 HDAC5ENSG00000108840Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*ENSMUSG0000002631357
Hdac7 / Q8C2B3 / Histone deacetylase 7 / Q8WUI4*ENSMUSG0000002247538
Hdac9 / histone deacetylase 9 / Q9UKV0*ENSMUSG0000000469827
Hdac6 / Q9Z2V5 / Histone deacetylase 6 / Q9UBN7*ENSMUSG0000003116122
Hdac10 / Q6P3E7 / Histone deacetylase 10 / Q969S8*ENSMUSG0000006290610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017320  Histone deacetylase class II, eukaryotic
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR024643  Histone deacetylase, glutamine rich N-terminal domain
 IPR030703  Histone deacetylase 5
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0010832 negative regulation of myotube differentiation IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fli1tm1Dkw/Fli1tm1Dkw
Genetic Background: either: B6.Cg-Fli1tm1Dkw or (involves: CD-1) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Camta2)1Eno/0
Genetic Background: involves: 129S2/SvPas

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fli1tm1Dkw/Fli1tm1Dkw
Genetic Background: either: B6.Cg-Fli1tm1Dkw or (involves: CD-1) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pkd2tm2Som/Pkd2tm2Som
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Hdac4tm1Eno/Hdac4tm2.1Eno,Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * 129S/SvEv * 129S2/SvPas

Allelic Composition: Hdac4tm1Eno/Hdac4+,Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9+
Genetic Background: involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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