ENSG00000108840


Homo sapiens

Features
Gene ID: ENSG00000108840
  
Biological name :HDAC5
  
Synonyms : HDAC5 / histone deacetylase 5 / Q9UQL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 44076746
Gene end: 44123702
  
Corresponding Affymetrix probe sets: 202455_at (Human Genome U133 Plus 2.0 Array)   229408_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468485
Ensembl peptide - ENSP00000465393
Ensembl peptide - ENSP00000468004
Ensembl peptide - ENSP00000225983
Ensembl peptide - ENSP00000337290
Ensembl peptide - ENSP00000465227
Ensembl peptide - ENSP00000465229
NCBI entrez gene - 10014     See in Manteia.
OMIM - 605315
RefSeq - XM_017023996
RefSeq - XM_017023989
RefSeq - XM_017023990
RefSeq - XM_017023991
RefSeq - XM_017023992
RefSeq - XM_017023993
RefSeq - XM_017023994
RefSeq - XM_017023995
RefSeq - NM_001015053
RefSeq - NM_005474
RefSeq - XM_005256905
RefSeq - XM_005256906
RefSeq - XM_011524149
RefSeq - XM_011524150
RefSeq - XM_017023988
RefSeq Peptide - NP_001015053
RefSeq Peptide - NP_005465
swissprot - K7ES01
swissprot - K7EJL6
swissprot - K7EJL4
swissprot - Q9UQL6
swissprot - K7EJZ7
Ensembl - ENSG00000108840
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac5ENSDARG00000075139Danio rerio
 Hdac5ENSMUSG00000008855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HDAC4 / P56524 / histone deacetylase 4ENSG0000006802459
HDAC9 / Q9UKV0 / histone deacetylase 9ENSG0000004805257
HDAC7 / Q8WUI4 / histone deacetylase 7ENSG0000006127340
HDAC6 / Q9UBN7 / histone deacetylase 6ENSG0000009463123
HDAC10 / Q969S8 / histone deacetylase 10ENSG0000010042911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR017320  Histone deacetylase class II, eukaryotic
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR024643  Histone deacetylase, glutamine rich N-terminal domain
 IPR030703  Histone deacetylase 5
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006342 chromatin silencing TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IMP
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0010830 regulation of myotube differentiation ISS
 biological_processGO:0010832 negative regulation of myotube differentiation IMP
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030183 B cell differentiation TAS
 biological_processGO:0032869 cellular response to insulin stimulus NAS
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0042113 B cell activation TAS
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043393 regulation of protein binding IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP
 cellular_componentGO:0000118 histone deacetylase complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IMP
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IPI


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112333 NR2E1 / Q9Y466 / nuclear receptor subfamily 2 group E member 1  / complex






 

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