ENSG00000112333


Homo sapiens

Features
Gene ID: ENSG00000112333
  
Biological name :NR2E1
  
Synonyms : NR2E1 / nuclear receptor subfamily 2 group E member 1 / Q9Y466
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q21
Gene start: 108166058
Gene end: 108188809
  
Corresponding Affymetrix probe sets: 207443_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357979
Ensembl peptide - ENSP00000416908
Ensembl peptide - ENSP00000357982
NCBI entrez gene - 7101     See in Manteia.
OMIM - 603849
RefSeq - NM_003269
RefSeq - NM_001286102
RefSeq Peptide - NP_001273031
RefSeq Peptide - NP_003260
swissprot - Q9Y466
swissprot - B6ZGT9
swissprot - A6PVF6
Ensembl - ENSG00000112333
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2e1ENSDARG00000017107Danio rerio
 NR2E1ENSGALG00000015305Gallus gallus
 Nr2e1ENSMUSG00000019803Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR2E3 / Q9Y5X4 / nuclear receptor subfamily 2 group E member 3ENSG0000027857041
NR2F6 / P10588 / nuclear receptor subfamily 2 group F member 6ENSG0000016011333
NR2F1 / P10589 / nuclear receptor subfamily 2 group F member 1ENSG0000017574533
NR2F2 / P24468 / nuclear receptor subfamily 2 group F member 2ENSG0000018555133
NR2C2 / P49116 / nuclear receptor subfamily 2 group C member 2ENSG0000017746332
NR2C1 / P13056 / nuclear receptor subfamily 2 group C member 1ENSG0000012079830
RXRA / P19793 / retinoid X receptor alphaENSG0000018635030
RXRG / P48443 / retinoid X receptor gammaENSG0000014317129
HNF4G / Q14541 / hepatocyte nuclear factor 4 gammaENSG0000016474928
HNF4A / P41235 / hepatocyte nuclear factor 4 alphaENSG0000010107628
RXRB / P28702 / retinoid X receptor betaENSG0000020423128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0002118 aggressive behavior IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0021542 dentate gyrus development IEA
 biological_processGO:0021764 amygdala development IEA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0021819 layer formation in cerebral cortex IEA
 biological_processGO:0021872 forebrain generation of neurons IEA
 biological_processGO:0021895 cerebral cortex neuron differentiation IEA
 biological_processGO:0021960 anterior commissure morphogenesis IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048712 negative regulation of astrocyte differentiation IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:0051128 regulation of cellular component organization IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060164 regulation of timing of neuron differentiation IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0090049 regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 biological_processGO:2000648 positive regulation of stem cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000061273 HDAC7 / Q8WUI4 / histone deacetylase 7  / complex
 ENSG00000108840 HDAC5 / Q9UQL6 / histone deacetylase 5  / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex






 

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