ENSG00000143171


Homo sapiens

Features
Gene ID: ENSG00000143171
  
Biological name :RXRG
  
Synonyms : P48443 / retinoid X receptor gamma / RXRG
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.3
Gene start: 165400917
Gene end: 165445355
  
Corresponding Affymetrix probe sets: 205954_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482458
Ensembl peptide - ENSP00000352900
NCBI entrez gene - 6258     See in Manteia.
OMIM - 180247
RefSeq - NM_001256570
RefSeq - NM_001256571
RefSeq - NM_006917
RefSeq Peptide - NP_008848
RefSeq Peptide - NP_001243499
RefSeq Peptide - NP_001243500
swissprot - P48443
swissprot - F1D8Q7
swissprot - A0A087WZ88
Ensembl - ENSG00000143171
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxrgbENSDARG00000004697Danio rerio
 RXRGENSGALG00000040730Gallus gallus
 RxrgENSMUSG00000015843Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RXRA / P19793 / retinoid X receptor alphaENSG0000018635070
RXRB / P28702 / retinoid X receptor betaENSG0000020423165
NR2F1 / P10589 / nuclear receptor subfamily 2 group F member 1ENSG0000017574533
NR2F2 / P24468 / nuclear receptor subfamily 2 group F member 2ENSG0000018555133
NR2F6 / P10588 / nuclear receptor subfamily 2 group F member 6ENSG0000016011332
HNF4A / P41235 / hepatocyte nuclear factor 4 alphaENSG0000010107632
HNF4G / Q14541 / hepatocyte nuclear factor 4 gammaENSG0000016474931
NR2C1 / P13056 / nuclear receptor subfamily 2 group C member 1ENSG0000012079830
NR2C2 / P49116 / nuclear receptor subfamily 2 group C member 2ENSG0000017746330
NR2E3 / Q9Y5X4 / nuclear receptor subfamily 2 group E member 3ENSG0000027857029
NR2E1 / Q9Y466 / nuclear receptor subfamily 2 group E member 1ENSG0000011233326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000003  Retinoid X receptor/HNF4
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR021780  Nuclear/hormone receptor activator site AF-1
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048384 retinoic acid receptor signaling pathway IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004886 9-cis retinoic acid receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172819 RARG / P13631 / retinoic acid receptor gamma  / complex
 ENSG00000143320 CRABP2 / P29373 / cellular retinoic acid binding protein 2  / complex / reaction






 

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