ENSG00000172819


Homo sapiens

Features
Gene ID: ENSG00000172819
  
Biological name :RARG
  
Synonyms : P13631 / RARG / retinoic acid receptor gamma
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 53210567
Gene end: 53232980
  
Corresponding Affymetrix probe sets: 204188_s_at (Human Genome U133 Plus 2.0 Array)   204189_at (Human Genome U133 Plus 2.0 Array)   217178_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454604
Ensembl peptide - ENSP00000388510
Ensembl peptide - ENSP00000377947
Ensembl peptide - ENSP00000343698
Ensembl peptide - ENSP00000454385
Ensembl peptide - ENSP00000454417
Ensembl peptide - ENSP00000444335
NCBI entrez gene - 5916     See in Manteia.
OMIM - 180190
RefSeq - NM_001243732
RefSeq - NM_000966
RefSeq - NM_001042728
RefSeq - NM_001243730
RefSeq - NM_001243731
RefSeq Peptide - NP_000957
RefSeq Peptide - NP_001230661
RefSeq Peptide - NP_001230660
RefSeq Peptide - NP_001230659
RefSeq Peptide - NP_001036193
swissprot - P13631
swissprot - A8K3H3
swissprot - F1D8P1
swissprot - H3BMH6
swissprot - H3BMK1
swissprot - H3BMY6
Ensembl - ENSG00000172819
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rargaENSDARG00000034117Danio rerio
 rargbENSDARG00000054003Danio rerio
 RargENSMUSG00000001288Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RARB / P10826 / retinoic acid receptor betaENSG0000007709273
RARA / P10276 / retinoic acid receptor alphaENSG0000013175969
THRA / P10827 / thyroid hormone receptor, alphaENSG0000012635130
THRB / P10828 / thyroid hormone receptor betaENSG0000015109029
NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2ENSG0000013140828
NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3ENSG0000002543427
NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4ENSG0000001250425
NR1I2 / O75469 / nuclear receptor subfamily 1 group I member 2ENSG0000014485225
VDR / P11473 / vitamin D receptorENSG0000011142423
NR1I3 / Q14994 / nuclear receptor subfamily 1 group I member 3ENSG0000014325722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003078  Retinoic acid receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0002068 glandular epithelial cell development IEA
 biological_processGO:0003406 retinal pigment epithelium development IEA
 biological_processGO:0003417 growth plate cartilage development IEA
 biological_processGO:0003430 growth plate cartilage chondrocyte growth IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008361 regulation of cell size TAS
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0031076 embryonic camera-type eye development IEA
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0035116 embryonic hindlimb morphogenesis ISS
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043068 positive regulation of programmed cell death ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045637 regulation of myeloid cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048048 embryonic eye morphogenesis ISS
 biological_processGO:0048384 retinoic acid receptor signaling pathway IDA
 biological_processGO:0048608 reproductive structure development IEA
 biological_processGO:0048732 gland development IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060070 canonical Wnt signaling pathway TAS
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060349 bone morphogenesis IEA
 biological_processGO:0060429 epithelium development IEA
 biological_processGO:0060534 trachea cartilage development IEA
 biological_processGO:0060740 prostate gland epithelium morphogenesis IEA
 biological_processGO:0061037 negative regulation of cartilage development IEA
 biological_processGO:0070384 Harderian gland development IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex ISS
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003708 retinoic acid receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding ISS


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143171 RXRG / P48443 / retinoid X receptor gamma  / complex
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex
 ENSG00000143320 CRABP2 / P29373 / cellular retinoic acid binding protein 2  / complex / reaction






 

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