ENSG00000025434


Homo sapiens

Features
Gene ID: ENSG00000025434
  
Biological name :NR1H3
  
Synonyms : NR1H3 / nuclear receptor subfamily 1 group H member 3 / Q13133
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 47248300
Gene end: 47269032
  
Corresponding Affymetrix probe sets: 203920_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396132
Ensembl peptide - ENSP00000391005
Ensembl peptide - ENSP00000403696
Ensembl peptide - ENSP00000477707
Ensembl peptide - ENSP00000434650
Ensembl peptide - ENSP00000433271
Ensembl peptide - ENSP00000432073
Ensembl peptide - ENSP00000420656
Ensembl peptide - ENSP00000415591
Ensembl peptide - ENSP00000413095
Ensembl peptide - ENSP00000412636
Ensembl peptide - ENSP00000407716
Ensembl peptide - ENSP00000406692
Ensembl peptide - ENSP00000403798
Ensembl peptide - ENSP00000378793
Ensembl peptide - ENSP00000384745
Ensembl peptide - ENSP00000385073
Ensembl peptide - ENSP00000385801
Ensembl peptide - ENSP00000387946
NCBI entrez gene - 10062     See in Manteia.
OMIM - 602423
RefSeq - XM_017017058
RefSeq - NM_001251935
RefSeq - NM_005693
RefSeq - XM_005252705
RefSeq - XM_005252706
RefSeq - XM_005252707
RefSeq - XM_005252709
RefSeq - XM_005252710
RefSeq - XM_005252713
RefSeq - XM_005252715
RefSeq - XM_005252716
RefSeq - XM_005252718
RefSeq - XM_006718112
RefSeq - XM_006718113
RefSeq - XM_006718115
RefSeq - XM_006718116
RefSeq - XM_011519805
RefSeq - XM_011519806
RefSeq - XM_011519807
RefSeq - XM_011519808
RefSeq - XM_017017056
RefSeq - XM_017017057
RefSeq - NM_001130101
RefSeq - NM_001130102
RefSeq - NM_001251934
RefSeq Peptide - NP_005684
RefSeq Peptide - NP_001238863
RefSeq Peptide - NP_001238864
RefSeq Peptide - NP_001123573
RefSeq Peptide - NP_001123574
swissprot - C9JEC2
swissprot - C9JCS0
swissprot - C9JBS2
swissprot - C9J4R0
swissprot - C9J2C8
swissprot - E9PPA1
swissprot - F1D8N1
swissprot - F8WC63
swissprot - F8WEY6
swissprot - Q13133
swissprot - B4DXU5
swissprot - B5MBY7
swissprot - E9PLL4
swissprot - E9PID2
swissprot - C9JTS4
swissprot - C9JJ16
Ensembl - ENSG00000025434
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1h3ENSDARG00000098439Danio rerio
 NR1H3ENSGALG00000038059Gallus gallus
 Nr1h3ENSMUSG00000002108Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2ENSG0000013140861
NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4ENSG0000001250433
RARA / P10276 / retinoic acid receptor alphaENSG0000013175927
VDR / P11473 / vitamin D receptorENSG0000011142427
RARG / P13631 / retinoic acid receptor gammaENSG0000017281927
NR1I2 / O75469 / nuclear receptor subfamily 1 group I member 2ENSG0000014485226
RARB / P10826 / retinoic acid receptor betaENSG0000007709226
THRA / P10827 / thyroid hormone receptor, alphaENSG0000012635125
THRB / P10828 / thyroid hormone receptor betaENSG0000015109024
NR1I3 / Q14994 / nuclear receptor subfamily 1 group I member 3ENSG0000014325724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR023257  Liver X receptor
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IC
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IMP
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IDA
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0010887 negative regulation of cholesterol storage IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IMP
 biological_processGO:0032369 negative regulation of lipid transport IMP
 biological_processGO:0032376 positive regulation of cholesterol transport IDA
 biological_processGO:0032570 response to progesterone IDA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IDA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042752 regulation of circadian rhythm TAS
 biological_processGO:0043031 negative regulation of macrophage activation IEA
 biological_processGO:0043277 apoptotic cell clearance IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0044255 cellular lipid metabolic process IEA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IMP
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048550 negative regulation of pinocytosis IMP
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IMP
 biological_processGO:0055088 lipid homeostasis IEA
 biological_processGO:0055092 sterol homeostasis IEA
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway NAS
 biological_processGO:0070328 triglyceride homeostasis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090188 negative regulation of pancreatic juice secretion IEA
 biological_processGO:0090341 negative regulation of secretion of lysosomal enzymes IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0015485 cholesterol binding TAS
 molecular_functionGO:0032810 sterol response element binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
VLDLR internalisation and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex
 ENSG00000204231 RXRB / P28702 / retinoid X receptor beta  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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