ENSG00000101849


Homo sapiens

Features
Gene ID: ENSG00000101849
  
Biological name :TBL1X
  
Synonyms : O60907 / TBL1X / transducin beta like 1 X-linked
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.31
Gene start: 9463295
Gene end: 9741037
  
Corresponding Affymetrix probe sets: 1570293_at (Human Genome U133 Plus 2.0 Array)   201867_s_at (Human Genome U133 Plus 2.0 Array)   201868_s_at (Human Genome U133 Plus 2.0 Array)   201869_s_at (Human Genome U133 Plus 2.0 Array)   213400_s_at (Human Genome U133 Plus 2.0 Array)   213401_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407069
Ensembl peptide - ENSP00000415508
Ensembl peptide - ENSP00000496215
Ensembl peptide - ENSP00000495835
Ensembl peptide - ENSP00000495556
Ensembl peptide - ENSP00000495467
Ensembl peptide - ENSP00000493782
Ensembl peptide - ENSP00000217964
Ensembl peptide - ENSP00000370348
Ensembl peptide - ENSP00000385988
Ensembl peptide - ENSP00000394097
Ensembl peptide - ENSP00000397878
Ensembl peptide - ENSP00000402923
NCBI entrez gene - 6907     See in Manteia.
OMIM - 300196
RefSeq - XM_011545571
RefSeq - NM_001139466
RefSeq - NM_001139467
RefSeq - NM_001139468
RefSeq - NM_005647
RefSeq Peptide - NP_001132940
RefSeq Peptide - NP_005638
RefSeq Peptide - NP_001132938
RefSeq Peptide - NP_001132939
swissprot - C9J5F9
swissprot - A0A024RBV9
swissprot - C9JP56
swissprot - C9JCW3
swissprot - O60907
swissprot - C9JYQ8
Ensembl - ENSG00000101849
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbl1xENSDARG00000060438Danio rerio
 TBL1XENSGALG00000040006Gallus gallus
 Tbl1xENSMUSG00000025246Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBL1Y / Q9BQ87 / transducin beta like 1 Y-linkedENSG0000009237782
Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1ENSG0000017756578
THOC3 / Q96J01 / THO complex 3ENSG0000005159613


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006594  LIS1 homology motif
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0016575 histone deacetylation IBA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0003714 transcription corepressor activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163586 FABP1 / P07148 / fatty acid binding protein 1  / reaction
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / complex
 ENSG00000186951 PPARA / Q07869 / peroxisome proliferator activated receptor alpha  / reaction / complex
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex / reaction
 ENSG00000204231 RXRB / P28702 / retinoid X receptor beta  / complex
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / complex
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / complex / reaction
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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