ENSG00000204231


Homo sapiens

Features
Gene ID: ENSG00000204231
  
Biological name :RXRB
  
Synonyms : P28702 / retinoid X receptor beta / RXRB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 33193588
Gene end: 33200688
  
Corresponding Affymetrix probe sets: 209148_at (Human Genome U133 Plus 2.0 Array)   215098_at (Human Genome U133 Plus 2.0 Array)   215099_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363817
Ensembl peptide - ENSP00000431369
Ensembl peptide - ENSP00000363812
NCBI entrez gene - 6257     See in Manteia.
OMIM - 180246
RefSeq - XM_017011176
RefSeq - NM_001270401
RefSeq - NM_001291989
RefSeq - NM_021976
RefSeq - XM_005249278
RefSeq - XM_011514796
RefSeq Peptide - NP_068811
RefSeq Peptide - NP_001278918
RefSeq Peptide - NP_001257330
swissprot - A0A0S2Z570
swissprot - P28702
swissprot - E9PK75
swissprot - Q5STP9
Ensembl - ENSG00000204231
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxrbaENSDARG00000078954Danio rerio
 rxrbbENSDARG00000002006Danio rerio
 RxrbENSMUSG00000039656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RXRA / P19793 / retinoid X receptor alphaENSG0000018635060
RXRG / P48443 / retinoid X receptor gammaENSG0000014317156
NR2F2 / P24468 / nuclear receptor subfamily 2 group F member 2ENSG0000018555128
HNF4G / Q14541 / hepatocyte nuclear factor 4 gammaENSG0000016474928
HNF4A / P41235 / hepatocyte nuclear factor 4 alphaENSG0000010107628
NR2F1 / P10589 / nuclear receptor subfamily 2 group F member 1ENSG0000017574528
NR2F6 / P10588 / nuclear receptor subfamily 2 group F member 6ENSG0000016011327
NR2C1 / P13056 / nuclear receptor subfamily 2 group C member 1ENSG0000012079825
NR2C2 / P49116 / nuclear receptor subfamily 2 group C member 2ENSG0000017746325
NR2E3 / Q9Y5X4 / nuclear receptor subfamily 2 group E member 3ENSG0000027857025
NR2E1 / Q9Y466 / nuclear receptor subfamily 2 group E member 1ENSG0000011233322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000003  Retinoid X receptor/HNF4
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048384 retinoic acid receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0004886 9-cis retinoic acid receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex
 ENSG00000143320 CRABP2 / P29373 / cellular retinoic acid binding protein 2  / complex / reaction
 ENSG00000077092 RARB / P10826 / retinoic acid receptor beta  / complex
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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