ENSG00000171720


Homo sapiens

Features
Gene ID: ENSG00000171720
  
Biological name :HDAC3
  
Synonyms : HDAC3 / histone deacetylase 3 / O15379
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.3
Gene start: 141620876
Gene end: 141636870
  
Corresponding Affymetrix probe sets: 216326_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302967
Ensembl peptide - ENSP00000430782
Ensembl peptide - ENSP00000429099
NCBI entrez gene - 8841     See in Manteia.
OMIM - 605166
RefSeq - NM_003883
RefSeq - XM_011537697
RefSeq Peptide - NP_003874
swissprot - E7EW19
swissprot - E7ESJ6
swissprot - O15379
Ensembl - ENSG00000171720
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac3ENSDARG00000037514Danio rerio
 HDAC3ENSGALG00000002634Gallus gallus
 Hdac3ENSMUSG00000024454Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HDAC1 / Q13547 / histone deacetylase 1ENSG0000011647859
HDAC2 / Q92769 / histone deacetylase 2ENSG0000019659157
HDAC8 / Q9BY41 / histone deacetylase 8ENSG0000014709934
HDAC11 / Q96DB2 / histone deacetylase 11ENSG0000016351718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR003084  Histone deacetylase
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IDA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0031647 regulation of protein stability IDA
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IDA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046329 negative regulation of JNK cascade IMP
 biological_processGO:0051225 spindle assembly IMP
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0071498 cellular response to fluid shear stress IDA
 cellular_componentGO:0000118 histone deacetylase complex TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030332 cyclin binding IPI
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IDA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
NR1D1 (REV-ERBA) represses gene expression
p75NTR negatively regulates cell cycle via SC1
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Transcriptional regulation of white adipocyte differentiation
Association of TriC/CCT with target proteins during biosynthesis
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126368 NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1  / complex
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / reaction / complex
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex
 ENSG00000132170 PPARG / P37231 / peroxisome proliferator activated receptor gamma  / complex / reaction
 ENSG00000198795 Q96K83 / ZNF521 / zinc finger protein 521  / complex / reaction
 ENSG00000110851 PRDM4 / Q9UKN5 / PR/SET domain 4  / complex / reaction
 ENSG00000112333 NR2E1 / Q9Y466 / nuclear receptor subfamily 2 group E member 1  / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex / reaction
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / reaction / complex
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / reaction / complex
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / complex
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000204231 RXRB / P28702 / retinoid X receptor beta  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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