ENSG00000110851


Homo sapiens

Features
Gene ID: ENSG00000110851
  
Biological name :PRDM4
  
Synonyms : PRDM4 / PR/SET domain 4 / Q9UKN5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q23.3
Gene start: 107732866
Gene end: 107761272
  
Corresponding Affymetrix probe sets: 218329_at (Human Genome U133 Plus 2.0 Array)   49485_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449295
Ensembl peptide - ENSP00000228437
Ensembl peptide - ENSP00000446803
Ensembl peptide - ENSP00000448684
NCBI entrez gene - 11108     See in Manteia.
OMIM - 605780
RefSeq - XM_005268593
RefSeq - NM_012406
RefSeq Peptide - NP_036538
swissprot - F8VZQ2
swissprot - H0YIF6
swissprot - A0A024RBM7
swissprot - Q9UKN5
swissprot - F8VRG2
Ensembl - ENSG00000110851
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdm4ENSDARG00000017366Danio rerio
 PRDM4ENSGALG00000012619Gallus gallus
 Prdm4ENSMUSG00000035529Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRDM14 / Q9GZV8 / PR/SET domain 14ENSG0000014759614
PRDM6 / Q9NQX0 / PR/SET domain 6ENSG0000006145512
PRDM12 / Q9H4Q4 / PR/SET domain 12ENSG0000013071110
RTCB / Q9Y3I0 / RNA 2,3-cyclic phosphate and 5-OH ligaseENSG000001002207


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013087  Zinc finger C2H2-type
 IPR017124  PR-domain zinc finger protein PRDM4
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0032259 methylation IEA
 biological_processGO:0043985 histone H4-R3 methylation NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035097 histone methyltransferase complex NAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990226 histone methyltransferase binding NAS


Pathways (from Reactome)
Pathway description
p75NTR negatively regulates cell cycle via SC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / reaction / complex
 ENSG00000196591 HDAC2 / Q92769 / histone deacetylase 2  / complex / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction






 

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