ENSMUSG00000035529


Mus musculus

Features
Gene ID: ENSMUSG00000035529
  
Biological name :Prdm4
  
Synonyms : Prdm4 / PR domain zinc finger protein 4 / Q80V63
  
Possible biological names infered from orthology : PR/SET domain 4 / Q9UKN5
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 85891966
Gene end: 85917142
  
Corresponding Affymetrix probe sets: 10371420 (MoGene1.0st)   1452208_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151593
Ensembl peptide - ENSMUSP00000151931
Ensembl peptide - ENSMUSP00000041942
Ensembl peptide - ENSMUSP00000151513
NCBI entrez gene - 72843     See in Manteia.
MGI - MGI:1920093
RefSeq - XM_017314116
RefSeq - NM_001302887
RefSeq - NM_181650
RefSeq - XM_006514193
RefSeq - XM_006514194
RefSeq - XM_006514197
RefSeq - XM_011243582
RefSeq - XM_011243583
RefSeq - NM_001302886
RefSeq Peptide - NP_857633
RefSeq Peptide - NP_001289815
RefSeq Peptide - NP_001289816
swissprot - A0A1W2P779
swissprot - Q80V63
swissprot - A0A1W2P7C2
swissprot - A0A1X7SB67
Ensembl - ENSMUSG00000035529
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdm4ENSDARG00000017366Danio rerio
 PRDM4ENSGALG00000012619Gallus gallus
 PRDM4ENSG00000110851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9Q3T6 / Prdm14 / PR domain containing 14 / Q9GZV8* / PR/SET domain 14*ENSMUSG0000004241414
Prdm6 / Q3UZD5 / Putative histone-lysine N-methyltransferase PRDM6 / Q9NQX0* / PR/SET domain 6*ENSMUSG0000006937812
A2AJ77 / Prdm12 / PR domain zinc finger protein 12 / Q9H4Q4* / PR/SET domain 12*ENSMUSG0000007946610
Rtcb / Q99LF4 / tRNA-splicing ligase RtcB homolog / Q9Y3I0* / RNA 2,3-cyclic phosphate and 5-OH ligase*ENSMUSG000000017837


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013087  Zinc finger C2H2-type
 IPR017124  PR-domain zinc finger protein PRDM4
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0035097 histone methyltransferase complex IPI
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990226 histone methyltransferase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prdm4tm1b(EUCOMM)Liz/Prdm4tm1b(EUCOMM)Liz
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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