ENSMUSG00000042414


Mus musculus

Features
Gene ID: ENSMUSG00000042414
  
Biological name :Prdm14
  
Synonyms : E9Q3T6 / Prdm14 / PR domain containing 14
  
Possible biological names infered from orthology : PR/SET domain 14 / Q9GZV8
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A3
Gene start: 13113457
Gene end: 13127163
  
Corresponding Affymetrix probe sets: 10353127 (MoGene1.0st)   1444390_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044245
NCBI entrez gene - 383491     See in Manteia.
MGI - MGI:3588194
RefSeq - NM_001081209
RefSeq Peptide - NP_001074678
swissprot - E9Q3T6
Ensembl - ENSMUSG00000042414
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRDM14ENSG00000147596Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdm6 / Q3UZD5 / Putative histone-lysine N-methyltransferase PRDM6 / Q9NQX0* / PR/SET domain 6*ENSMUSG0000006937823
Prdm4 / Q80V63 / PR domain zinc finger protein 4 / Q9UKN5* / PR/SET domain 4*ENSMUSG0000003552920
A2AJ77 / Prdm12 / PR domain zinc finger protein 12 / Q9H4Q4* / PR/SET domain 12*ENSMUSG0000007946619
Rtcb / Q99LF4 / tRNA-splicing ligase RtcB homolog / Q9Y3I0* / RNA 2,3-cyclic phosphate and 5-OH ligase*ENSMUSG000000017837


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001827 inner cell mass cell fate commitment IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030718 germ-line stem cell population maintenance IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034972 histone H3-R26 methylation IDA
 biological_processGO:0040029 regulation of gene expression, epigenetic IGI
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0044030 regulation of DNA methylation IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0060817 inactivation of paternal X chromosome IMP
 biological_processGO:1902093 positive regulation of flagellated sperm motility IMP
 biological_processGO:1902459 positive regulation of stem cell population maintenance IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hrm1Btlr/Hrm1Btlr
Genetic Background: C57BL/6J-Hrm1Btlr

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Hrm1Btlr/Hrm1Btlr
Genetic Background: C57BL/6J-Hrm1Btlr

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0004806 absent germ cells "absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hrm1Btlr/Hrm1Btlr
Genetic Background: C57BL/6J-Hrm1Btlr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0008391 abnormal primordial germ cell morphology "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

Allelic Composition: Prdm14tm1e(EUCOMM)Wtsi/Prdm14tm1e(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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