ENSMUSG00000001783


Mus musculus

Features
Gene ID: ENSMUSG00000001783
  
Biological name :Rtcb
  
Synonyms : Q99LF4 / Rtcb / tRNA-splicing ligase RtcB homolog
  
Possible biological names infered from orthology : Q9Y3I0 / RNA 2,3-cyclic phosphate and 5-OH ligase
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 85938637
Gene end: 85957823
  
Corresponding Affymetrix probe sets: 10371432 (MoGene1.0st)   1420129_s_at (Mouse Genome 430 2.0 Array)   1420130_s_at (Mouse Genome 430 2.0 Array)   1423880_at (Mouse Genome 430 2.0 Array)   1439097_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001834
NCBI entrez gene - 28088     See in Manteia.
MGI - MGI:106379
RefSeq - NM_145422
RefSeq Peptide - NP_663397
swissprot - Q99LF4
Ensembl - ENSMUSG00000001783
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdm4ENSDARG00000017366Danio rerio
 RTCBENSG00000100220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdm4 / Q80V63 / PR domain zinc finger protein 4 / Q9UKN5* / PR/SET domain 4*ENSMUSG0000003552911
Prdm6 / Q3UZD5 / Putative histone-lysine N-methyltransferase PRDM6 / Q9NQX0* / PR/SET domain 6*ENSMUSG000000693789
E9Q3T6 / Prdm14 / PR domain containing 14 / Q9GZV8* / PR/SET domain 14*ENSMUSG000000424148
A2AJ77 / Prdm12 / PR domain zinc finger protein 12 / Q9H4Q4* / PR/SET domain 12*ENSMUSG000000794666


Protein motifs (from Interpro)
Interpro ID Name
 IPR001233  tRNA-splicing ligase, RtcB
 IPR027513  tRNA-splicing ligase RtcB homologue, eukaryotic
 IPR036025  tRNA-splicing ligase RtcB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation ISO
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0008033 tRNA processing IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0072669 tRNA-splicing ligase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003972 RNA ligase (ATP) activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008452 RNA ligase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0017166 vinculin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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