ENSG00000061455


Homo sapiens

Features
Gene ID: ENSG00000061455
  
Biological name :PRDM6
  
Synonyms : PRDM6 / PR/SET domain 6 / Q9NQX0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q23.2
Gene start: 123089121
Gene end: 123194266
  
Corresponding Affymetrix probe sets: 230311_s_at (Human Genome U133 Plus 2.0 Array)   236577_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384725
Ensembl peptide - ENSP00000390919
NCBI entrez gene - 93166     See in Manteia.
OMIM - 616982
RefSeq - XM_011543726
RefSeq - NM_001136239
RefSeq Peptide - NP_001129711
swissprot - Q9NQX0
swissprot - H7BZR2
Ensembl - ENSG00000061455
  
Related genetic diseases (OMIM): 617039 - Patent ductus arteriosus 3, 617039

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRDM6ENSGALG00000005351Gallus gallus
 Prdm6ENSMUSG00000069378Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRDM14 / Q9GZV8 / PR/SET domain 14ENSG0000014759622
PRDM12 / Q9H4Q4 / PR/SET domain 12ENSG0000013071117
PRDM4 / Q9UKN5 / PR/SET domain 4ENSG0000011085117
RTCB / Q9Y3I0 / RNA 2,3-cyclic phosphate and 5-OH ligaseENSG000001002208


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001643 Patent ductus arteriosus 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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