ENSG00000196591


Homo sapiens

Features
Gene ID: ENSG00000196591
  
Biological name :HDAC2
  
Synonyms : HDAC2 / histone deacetylase 2 / Q92769
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q21
Gene start: 113933028
Gene end: 114011308
  
Corresponding Affymetrix probe sets: 201833_at (Human Genome U133 Plus 2.0 Array)   242141_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427861
Ensembl peptide - ENSP00000430432
Ensembl peptide - ENSP00000430008
Ensembl peptide - ENSP00000429901
Ensembl peptide - ENSP00000429236
Ensembl peptide - ENSP00000428989
Ensembl peptide - ENSP00000428861
Ensembl peptide - ENSP00000428653
Ensembl peptide - ENSP00000428599
Ensembl peptide - ENSP00000428024
Ensembl peptide - ENSP00000357621
Ensembl peptide - ENSP00000417026
NCBI entrez gene - 3066     See in Manteia.
OMIM - 605164
RefSeq - NM_001527
RefSeq - XM_011535788
RefSeq - XM_017010799
RefSeq Peptide - NP_001518
swissprot - E5RG37
swissprot - E5RFP9
swissprot - E5RK19
swissprot - H3BM24
swissprot - Q92769
swissprot - E5RFI6
swissprot - E5RJ04
swissprot - E5RHE7
swissprot - E5RH52
swissprot - E5RGV4
Ensembl - ENSG00000196591
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HDAC2ENSGALG00000014991Gallus gallus
 Hdac2ENSMUSG00000019777Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HDAC1 / Q13547 / histone deacetylase 1ENSG0000011647885
HDAC3 / O15379 / histone deacetylase 3ENSG0000017172050
HDAC8 / Q9BY41 / histone deacetylase 8ENSG0000014709932
HDAC11 / Q96DB2 / histone deacetylase 11ENSG0000016351719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR003084  Histone deacetylase
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IC
 biological_processGO:0006344 maintenance of chromatin silencing IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009913 epidermal cell differentiation ISS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IMP
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0016358 dendrite development ISS
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032732 positive regulation of interleukin-1 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IC
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth ISS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042733 embryonic digit morphogenesis ISS
 biological_processGO:0043044 ATP-dependent chromatin remodeling HDA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0045347 negative regulation of MHC class II biosynthetic process IC
 biological_processGO:0045862 positive regulation of proteolysis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IC
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048149 behavioral response to ethanol IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060789 hair follicle placode formation ISS
 biological_processGO:0061000 negative regulation of dendritic spine development IEA
 biological_processGO:0061029 eyelid development in camera-type eye ISS
 biological_processGO:0061198 fungiform papilla formation ISS
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070932 histone H3 deacetylation ISS
 biological_processGO:0070933 histone H4 deacetylation ISS
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016580 Sin3 complex IDA
 cellular_componentGO:0016581 NuRD complex IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding HDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding HDA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity ISS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031492 nucleosomal DNA binding HDA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IMP
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0051059 NF-kappaB binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
p75NTR negatively regulates cell cycle via SC1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / complex / reaction
 ENSG00000084093 REST / Q13127 / RE1 silencing transcription factor  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000169375 SIN3A / Q96ST3 / SIN3 transcription regulator family member A  / complex
 ENSG00000089902 RCOR1 / Q9UKL0 / REST corepressor 1  / complex
 ENSG00000110851 PRDM4 / Q9UKN5 / PR/SET domain 4  / reaction / complex
 ENSG00000196591 HDAC2 / Q92769 / histone deacetylase 2  / complex
 ENSG00000004487 KDM1A / O60341 / lysine demethylase 1A  / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr