ENSG00000089902


Homo sapiens

Features
Gene ID: ENSG00000089902
  
Biological name :RCOR1
  
Synonyms : Q9UKL0 / RCOR1 / REST corepressor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.31
Gene start: 102592661
Gene end: 102730576
  
Corresponding Affymetrix probe sets: 212612_at (Human Genome U133 Plus 2.0 Array)   237041_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262241
Ensembl peptide - ENSP00000454204
NCBI entrez gene - 23186     See in Manteia.
OMIM - 607675
RefSeq - NM_015156
RefSeq Peptide - NP_055971
swissprot - Q9UKL0
swissprot - H0YNY4
Ensembl - ENSG00000089902
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rcor1ENSDARG00000031434Danio rerio
 RCOR1ENSGALG00000011384Gallus gallus
 Rcor1ENSMUSG00000037896Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RCOR3 / Q9P2K3 / REST corepressor 3ENSG0000011762556
RCOR2 / Q8IZ40 / REST corepressor 2ENSG0000016777147
NCOR1 / O75376 / nuclear receptor corepressor 1ENSG0000014102722
NCOR2 / Q9Y618 / nuclear receptor corepressor 2ENSG0000019649822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0070933 histone H4 deacetylation IDA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:1990391 DNA repair complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Regulation of PTEN gene transcription
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000084093 REST / Q13127 / RE1 silencing transcription factor  / complex
 ENSG00000004487 KDM1A / O60341 / lysine demethylase 1A  / complex
 ENSG00000196591 HDAC2 / Q92769 / histone deacetylase 2  / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex






 

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