ENSMUSG00000037896


Mus musculus

Features
Gene ID: ENSMUSG00000037896
  
Biological name :Rcor1
  
Synonyms : Q8CFE3 / Rcor1 / REST corepressor 1
  
Possible biological names infered from orthology : Q9UKL0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 111039351
Gene end: 111115901
  
Corresponding Affymetrix probe sets: 10398601 (MoGene1.0st)   1434336_s_at (Mouse Genome 430 2.0 Array)   1437545_at (Mouse Genome 430 2.0 Array)   1454932_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112089
Ensembl peptide - ENSMUSP00000082034
NCBI entrez gene - 217864     See in Manteia.
MGI - MGI:106340
RefSeq - NM_198023
RefSeq - XM_006515760
RefSeq Peptide - NP_932140
swissprot - A0A140T8R7
swissprot - Q8CFE3
Ensembl - ENSMUSG00000037896
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rcor1ENSDARG00000031434Danio rerio
 RCOR1ENSGALG00000011384Gallus gallus
 RCOR1ENSG00000089902Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rcor3 / Q6PGA0 / REST corepressor 3 / Q9P2K3*ENSMUSG0000003739565
Rcor2 / Q8C796 / REST corepressor 2 / Q8IZ40*ENSMUSG0000002496857
Ncor1 / nuclear receptor co-repressor 1 / O75376* / nuclear receptor corepressor 1*ENSMUSG0000001850124
Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*ENSMUSG0000002947821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0070933 histone H4 deacetylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:1990391 DNA repair complex IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019777 Hdac2 / histone deacetylase 2 / Q92769*  / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / complex
 ENSMUSG00000029249 Rest / Q8VIG1 / RE1-silencing transcription factor / Q13127*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex






 

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